舒肝解郁胶囊治疗帕金森病伴抑郁的疗效观察.docVIP

精品论文 参考文献 舒肝解郁胶囊治疗帕金森病伴抑郁的疗效观察 陈忠伦 段劲峰 （绵阳市中心医院神经内科 四川绵阳 621000） 【摘要】目的 观察舒肝解郁胶囊对帕金森病伴抑郁的临床治疗作用。方法 将66例帕金森病伴抑郁患者随机分为治疗组1组22例、治疗2组22例和对照组22例。对照组只进行常规治疗，不使用抗抑郁药。治疗组1组在常规治疗的基础上加用舒肝解郁胶囊，治疗2组在常规治疗的基础上加用盐酸帕罗西汀片。分别在治疗前及治疗后2 周、4 周和8 周通过HAMD量表对患者抑郁状况进行评价。结果 治疗4周后, 治疗1组及治疗2组的HAMD评分明显低于对照组，差异有统计学意义(Plt;0.05),这种差异在治疗第8周后更明显（P lt;0.01），治疗1组及治疗2组中轻度抑郁患者HAMD评分在治疗第2、4、8周均无显著差异（Pgt;0.05），而在两组中、重度抑郁患者中治疗的4、8周时HAMD评分有显著差异( P lt;0.05)。结论 舒肝解郁胶囊可明显改善帕金森患者的抑郁症状,尤其适合轻度抑郁患者，且无不良反应发生,可以提高帕金森患者的生活质量,值得临床推广。 【关键词】 帕金森病 抑郁症状 非运动症状 舒肝解郁胶囊 【中图分类号】R453 【文献标识码】A 【文章编号】2095-1752（2012）22-0125-02 Shugan Jieyu capsule Efficacy of the treatment of Parkinsons disease with depression *Chen Zhonglun, WangXin, Shu Muxiao , et al. *Department of Neurology,Mianyang central Hospital ,Mianyang 621000,China. 【Abstract】 Objective: To observe the clinical therapeutic effects of Shugan Jieyu capsule of Parkinsons disease with depression . Methods: 66 cases of Parkinsons disease with depression were randomly divided into treatment group , a group of 22 cases , treatment of 22 cases and a control group of 22 cases . The control group only conventional treatment, do not use antidepressants . Treatment group on the basis of the conventional treatment plus Shugan Jieyu capsules, treatment group 2 in the conventional therapy plus paroxetine hydrochloride tablets . Before treatment and after treatment, 2 weeks , 4 weeks and 8 weeks for patients suffering from depression HAMD scale evaluation . Results: After 4 weeks of treatment, the treatment group and treatment group 2 HAMD score was significantly lower than the control group , the difference was statistically significant (Plt;0.05) , this difference is more obvious after 8 weeks of treatment ( P lt; 0.01 )，4 and 8 weeks of treatment group 1 and group 2 treatment in patients with mild depression HAMD in the treatment of the first 2, 4 and 8 weeks no significant difference ( P gt; 0.05 ) , in both gr