血清Cysc、α1-m和RBP 联检对原发性高血压患者肾损害的早期诊断价值.docVIP

精品论文 参考文献 血清Cysc、α1-m和RBP 联检对原发性高血压患者肾损害的早期诊断价值 刘艺芹1 蒋玲2（通讯作者） 　　（1 江苏省连云港市经济技术开发区中云社区卫生服务中心 222067） 　　（2江苏省连云港市东方医院检验科 222042） 　　【摘要】目的：探讨了血清半胱氨酸蛋白霉抑制剂C(cystatinc, Cysc)、alpha;1微球蛋白（alpha;1-microglobulin,alpha;1-m）和视黄醇结合蛋白（retinol binding protein, RBP）联检对原发性高血压患者肾损害早期的临床价值。方法：选择96例原发性高血压患者，其中60例无肾病，36例伴高血压肾病，采用乳胶颗粒增强免疫比浊法检测血清Cysc，酶联法检测alpha;1-m，免疫透射比浊法检测血清RBP,并与35名正常健康人作比较。结果：患者血清Cysc、alpha;1-m和RBP水平均非常显著地高于正常人组（plt;0.01）,联检Cysc、alpha;1-m和RBP的阳性率明显高于单项。结论：血清Cysc、alpha;1-m和RBP是原发性高血压患者早期肾损害的良好指标，联检可提供较新的概念，有助于对患者肾脏损伤的早期诊断和疗效观察。 　　【关键词】原发性高血压 肾损害 血清半胱氨酸蛋白酶抑制剂C alpha;1微球蛋白 视黄醇结合蛋白 　　【中图分类号】R446 【文献标识码】A 【文章编号】2095-1752（2014）21-0294-02 　　The evaluation of early diagnosis on primary hypertension Nephropathies with Cysc、a1-m and RBP 　　Liu Yiqin1,Jiang Ling2△ （1.Zhongyun Community, Health Service, Lianyungang City Economic and Technological Development Zone, Jiangsu Province 222067；2.Oriental Hospital of Lian Yun gang,Jiang su.Provinse 222042） 　　【Abstract】Objective To explore the clinical significance of determination of Serum Cysc、a1-m and RBP levels in diagnosis of early renal damage in patients with primary hypertension nephropathies.Methods Serum Sysc(with simultaneously)、a1-m(with ELISA) and RBP(with immanoturbidi metric assay) levels were determined in 36 patients with primary hypertension, 60 cases no nephropathies, 36 cases nephropathies and 35 controls. Results Serum Cysc、alpha;1-m and RBP levels in patients with primary hypertension nephropathies were significantly higher than those in Controls(plt;0.01). Cysc、alpha;1-m and RBP showed that the sensitivity was 61.5%. Itrsquo;s evidently higher than one of them. Conclusions Cysc、alpha;1-m and RBP are good diagnostic waker of early renal damage in patients with primary hypertension nephropathies. The combined examination of Cysc、alpha;1-m and RBP may provide new ideas and can be very helpful with primary hypertension nephropathies and observing curativ