超声微探头检查在食管癌术前分期中的应用.docVIP

精品论文 参考文献 超声微探头检查在食管癌术前分期中的应用 李瑞光 梁婕 (新疆医科大学第三附属医院内镜中心 乌鲁木齐 830011) 　　【摘要】目的 探讨超声微探头在食管癌T、N分期的准确率及食管癌术前诊断的价值。方法 选择手术治疗的89例食管癌患者术前接受超声微探头检查，以手术探查和术后病理诊断结果为标准，评价超声微探头诊断食管癌浸润深度（T分期）和局部淋巴结转移（N分期）的准确率。结果 超声微探头检查诊断食管癌T110例，T2分期16例，T3分期45例，T4分期18例，与术后病理结果对照，肿瘤的T分期的准确率为89%（80/89），N分期的准确率为76%（68/89）。结论 超声微探头检查是诊断食管癌术前分期的有效方法，对指导术前制定治疗方案，评价预后有重要意义。 　　【关键词】食管癌 超声微探头 术前分期 　　【中图分类号】R730.4 【文献标识码】A 【文章编号】1672-5085（2013）48-0026-02 　　Research?on?relationship between longevity in Hetian Uygur population and polymorphisms and haplotypes of the klotho gene LI rui-guang.liang jie (Endoscopy center, The third Affiliated Hospital of Xinjiang Medical University, Urumqi 830011,China) 　　【Abstract】Objective To study the relationship between the Klotho gene polymorphism in exon 2, rs9536314 and rs9527025 and 4 Zone District rs564481, polymorphism of rs1207568 in the promoter region and longevity in Hetian Uygur population. Methods Genotyping were done regarding polymorphism of rs9536314 and rs9527025 and rs1207568 and the rs564481 in 112 cases of case group and 249 cases of control group by Multiplex SNaPshot reaction. Results There are no significant difference between case group and control group regarding genotype frequency, allele frequency and haplotype distribution in rs9536314, rs9527025, rs1207568 and rs564481 of Klotho gene (Pgt;0.05). Polymorphism of Klotho gene is not related to longevity the Uygur population according to correlation analysis (Pgt;0.05).Conclusions?There?are?no?correlation?between?polymorphism?of?Klotho?gene?in?rs9536314,?rs9527025,?rs1207568?and?rs564481?and?longevity?in?Xinjiang?Uygur?population. 　　【Key words】Klotho?gene longevity gene?polymorphism 　　食管癌是我国常见的消化道恶性肿瘤，作为食管癌术前分期的检查方法，超声微探头检查已被消化学术界普遍认可[1]，超声微探头经内镜活检钳通道进入食管腔内对病变进行检查，可以显示肿瘤组织与食管壁各层次的关系，根据病变累及及或浸润深度，以判断食管癌术前TN分期。食管癌的浸润深度及淋巴结转移的范围，一直是胸外科医师在术前选择治疗方案中十分关注的问题。普通内镜常难以判断食管癌的范围及浸润深度。超声内镜需要二次操作，对管腔狭窄患者难以接近近端病灶，以致临床使用受到限制，超声微探头可以直接经胃镜活检通道进入病变部位进