银杏达莫注射液联合胞磷胆碱钠治疗血管性痴呆临床观察.docVIP

精品论文 参考文献 银杏达莫注射液联合胞磷胆碱钠治疗血管性痴呆临床观察 长沙市精神病医院 老年科 湖南 410004 摘要：目的：观察银杏达莫注射液联合胞磷胆碱钠片治疗血管性痴呆的疗效及安全性。方法：血管性痴呆患者82例，随机分为对照组（40例）和观察组（42例）。对照组口服胞磷胆碱钠片每次0.2g（1片），3次/d，共服用8周。观察组在对照组治疗基础上，同时给予银杏达莫注射液20mL加入0.9%氯化钠250mL中静滴，1次/d，应用4周。两组患者均于治疗前及治疗8周后根据日常生活能力量表（ADL）、简易智能状况量表（MMSE）对患者进行评估及比较。同时，通过用药前后安全性指标检测，评价银杏达莫注射液的安全性。结果：8周后观察组总评分变化幅度与对照组治疗后总评分幅度相比，差异有统计学意义（plt;0.05）。临床研究中，未见药物所致的毒副作用及严重不良事件。结论：银杏达莫注射液联合胞磷胆碱钠能够改善血管性痴呆患者MMSE、ADL评分，提高患者的生存质量，且安全性和耐受性良好。 关键词：血管性痴呆；银杏达莫；胞磷胆碱钠 Abstract：Objective：To observe the clinical efficacy and safety of Ginkgo Leaf Extract and Dipyridamole injection combined with Citicoline sodium on vascular dementia.Methods：eighty-two cases with vascular dementia were selected from January，2011 to December，2012，and were randomly divided into observation group（n=42）and control group（n=40）.Citicoline sodium tablet with the dose of 0.2 g was taken orally to control group，three times in a day，the course was 8 weeks；The observation group based on the treatment in control group，while giving the Ginkgo Leaf Extract and Dipyridamole injection with the dose of 20mL plused to 250mL Sodium Chloride injection by intravenous drip，one time in a day，the course was 4 weeks.The clinical efficacy was evaluated by activities of daily living scale（ADL）and Mini Mental State Examination（MMSE），the safety was evaluated by safety index in two groups 8 weeks before and after treatment.Results：The change range of total scores in observation group compared with that in control group at 8 weeks after treatment，there was a statistical difference（Plt; 0.05）.Conclusion：Ginkgo Leaf Extract and Dipyridamole injection combined with Citicoline sodium is effective and safe in the treatment of patients with Vascular dementia. Key words：Vascular dementia；Ginkgo Leaf Extract and Dipyridamole injection；Citicoline sodium 血管性痴呆（vascular dementia，VD）属脑血管病所致精神障碍临床类型中的一种类型，是指由脑血管疾病导致脑供血障碍而出现的智能全面减退，包括记忆力、认知力、情绪与行为等一系列的症状与体征，也是脑血管疾病的临床转归的一种类型。临床上采用银杏达莫注射液联合胞磷胆碱钠片治疗血管性痴呆，观察其治疗效果及安全性，现报告