非甾体类消炎药预防老年白内障患者术后黄斑水肿的研究.docVIP

精品论文 参考文献 非甾体类消炎药预防老年白内障患者术后黄斑水肿的研究 （ 爱尔眼科医院集团宜昌爱尔眼科医院；湖北宜昌 443000） 　　摘要： 目的 探讨行超声乳化白内障吸除术前与术后给予非甾体类抗炎药对黄斑水肿的预防效果。方法 将行白内障超声乳化吸除术的老年白内障患者随机分为A、B、C、D四组，A组术前3d口服布洛芬缓释胶囊，B组术前3d给予双氯芬酸钠滴眼液，C组术后开始给予双氯芬酸钠滴眼液，D组术前术后不使用任何非甾体类抗炎药，术后A、B、C三组均给予典必殊滴眼液和双氯芬酸钠滴眼液，D组仅给予典必殊滴眼液。分别于术后3d，1、2、4、6、10周随访，观察各组间最佳矫正视力、黄斑水肿发生率和黄斑中央区厚度。结果 术后3d、1、2周各组间黄斑水肿的发生情况无统计学意义（Pgt;0.05），术后4、6和10周，A、B、C、D组黄斑水肿的发生率依次降低，差异均具有统计学意义（Plt;0.05）。在术后各期，四组黄斑中央视网膜厚度差异无统计学意义。结论 行超声乳化白内障吸除术的白内障患者，术前使用非甾体类消炎药可更好减少黄斑水肿的发生，且口服的效果比局部用滴眼液的效果要好。 　　关键词：非甾体类药物；白内障；黄斑水肿 　　Role of topical NSAIDs in inhibiting macular edema after phacoemulsification in patients with cataract 　　Yan Hao1, Sun dan1, Wangguohua1(Corresponding author) 　　（1 Loversquo;s eye hospital group yichang love eye Hospital, Yichang, 443000, China） 　　ABSTRACT: Objective To investigate the efficacy of a steroidal ophthalmic solution administered prophylactically against macular edema after phacoemulsification and intraocular lens implantation and to assess macular thickness changes using optical coherence tomography(OCT) Methods In this study, patients with cataract were randomized to A group(n=48), B group(n=46), C group(n=50) and D group(n=44). Patients in the A group received ibuprofen sustained release capsules, 2 times daily for 3 days before operation. Patients in the B group received diclofenac sodium eye drops 4 times daily for 3 days before operation. Patients in the C group received diclofenac sodium eye drops 4 times daily for 3 days after operation. Patients in the D group received no NSAIDs. Macular edema incidence were measured by follow-up visit, and central field retinal thickness was measured by OCT. Results Based on OCT, There was no significant difference among A, B, C and D group within 4weeks after phacoemulsification. Macular edema incidence of A, B, C and D group were decreased systematically. There was no significant difference of the central subfield retinal thickness values between 4 groups. Conclusions This study suggests that adding