齐拉西酮与利培酮治疗女性精神分裂症的研究.docVIP

精品论文 参考文献 齐拉西酮与利培酮治疗女性精神分裂症的研究 潘国良（沈阳市精神卫生中心 110168） 【中图分类号】R971+.41 【文献标识码】A 【文章编号】1672-5085（2013）02-0113-02 【摘要】 目的 比较齐拉西酮与利培酮治疗女性精神分裂症的疗效及副反应。方法 100例符合ICD-10诊断标准的女性精神分裂症患者随机分为两组各50例，分别给与齐拉西酮和利培酮治疗8周，采用阳性症状与阴性症状量表（PANSS）及副反应量表（TESS）评定疗效及不良反应。结果 治疗8周后，齐拉西酮组的显效率为82%，有效率为94%；利培酮组的显效率为80%，有效率为92%。两组疗效无显著性差异（P＞0.05）。齐拉西酮组的阴性症状减分率更高，齐拉西酮组的不良反应发生率为18%，利培酮组为28%，有显著性差异（Plt;0.05），齐拉西酮组的泌乳素水平低于利培酮组（Plt;0.05）。结论 齐拉西酮和利培酮对精神分裂症的总体疗效相当，齐拉西酮不影响泌乳素水平，更适治疗女性患者。 【关键词】 齐拉西酮 利培酮 精神分裂症 The study of Ziprasidone and Risperidone in the Treatment of Women Schizophrenia 【Abstract】Objective To compare the efficacy and safety of ziprasidone and risperidone in the treatment of women schizophrenia. Methods 100 women patients with schizophrenia were stochastic allocated to two groups treated with ziprasidone and risperidone for 8 weeks. The Positive and Negative Syndrome Scale (PANSS) and Treatment Emergent Side Effect Scale were used to evaluate the efficacy and side effects. Results The significant efficacy rates of ziprasidone group was 82% and the efficacy rates was 94% after 8 weeks, while that was 80% and 92% in risperidone group. There was no significant difference between the two groups(P＞0.05). The reduction rate of negative syndrome was higher in ziprasidone group. The incidence rate of adverse effect was 18% in ziprasidone group and that was 28% in risperidone group, and there had a significant difference between them（Plt;0.05）.The level of PRL in ziprasidone was lower than that of risperidone. Conclusion Ziprasidone is as effective as risperidone for the treatment of women schizophrenia, but ziprasidone canrsquo;t affect the level of PRL and it was more fit for women patients. 【Key Words】 Ziprasidone risperidone schizophrenia 齐拉西酮和利培酮作为新型非典型抗精神病药物，治疗精神分裂症的临床应用中，具有良好的临床效果，现将齐拉西酮和利培酮治疗女性精神分裂症患者的临床疗效比较报告如下。 1 对象与方法 1.1 对象 研究对象为2010年6月至2012年8月在沈阳市精神卫生中心住院和门诊的女性病人100人，年龄为19-54岁，平均年龄30plusmn;18.43岁，入组标准：1）符合精神与行为障碍分类诊断标准（ICD-10）的精神分裂症诊断；2）PANSS总分ge