抗生素PPT课件（英文精品） Severe acute pancreatitisPPT.ppt

Severe acute pancreatitis;History;Physical and laboratory examinations;Which evaluations would you perform to determine if the patient has severe pancreatitis?;Initial tests and treatment;Ranson score: a pancreatitis-specific severity of illness score;The patient has eight positive Ranson criteria;Would you start prophylactic antibiotics?;Penetration of pancreatic tissue and pancreatic juice by antimicrobial agents;What is this patient’s risk of developing infection?;Incidence of peripancreatic infection after acute pancreatitis;Day 14;How long would you administer antibiotic prophylaxis?;Prophylactic antibiotics for severe acute pancreatitisFirst double-blind, placebo-controlled trial;Results: intention-to-treat analysis (n=114);Prophylactic antibiotics for severe acute pancreatitis: double-blind, placebo-controlled trial;Prophylactic antibiotics for severe acute pancreatitis: trial results;The downside of prolonged antibiotic prophylaxis;Prophylactic antibiotics for severe acute pancreatitis;What antibiotic regimen was prescribed initially?;The patient’s condition improves;The patient develops multiple organ dysfunction syndrome;Repeat CT scan shows a large peripancreatic fluid collection;What action(s) should be taken now?;What specimen(s) would you collect?;Incidence of infected pancreatitis when sought by fine-needle aspiration;Results of culture and susceptibility testing;Microbiology of infected pancreatic necrosis (%);Therapy;Outcome;Key learning points;AIM core principles