基于DTI图像的脑干肿瘤术前路径自动规划设计.pdfVIP

RESEARCH WORK 论 著 基于DTI图像的脑干肿瘤术前路径 自动规划设计 1 1 2 2 2 1 李苗 ，刘佳 ，泮长存 ，汤劼 ，张力伟 ，廖洪恩 1.清华大学 医学院生物医学工程系，北京 100084 ；2.首都医科大学附属北京天坛医院 神经外科，北京 100050 [摘 要] 目的 本研究提出基于磁共振弥散张量成像（Diffusion Tensor Imaging ，DTI ）图像的脑干肿瘤术前路径自动规划设 计，对重要组织结构的有效规避和减少手术致残率具有重要意义。方法 本研究将DTI功能像与核磁共振结构像相结合，进 行脑干肿瘤术前路径自动规划。首先对DTI 图像进行变形矫正，将DTI功能像与核磁共振结构像进行配准，然后提取两种图 像的关键区域信息，利用引力斥力模型通过样条曲线插值对术前信息进行路径自动规划设计。结果 该方法提取术前的纤维 束与组织结构信息，完成术前自动路径规划，直观的实现了对关键组织最大化规避的路径规划设计。结论 该方法通过对术 前DTI 图像的矫正配准以及区域纤维束的追踪提取，为医生在术中规避重要组织区域提供直观信息。 [关键词] 弥散张量成像；脑干肿瘤；图像配准；纤维束；路径规划 Design of Automatic preoperative path planning of brain Stem Tumor Surgery based on DTI 1 1 2 2 2 1 LI Miao , LIU Jia , PAN Changcun , TANG Jie , ZHANG Liwei , LIAO Hongen 1.Department of Biomedical Engineering, School of Medicine, Tsinghua University, Beijing 100084, China;2.Department of Neurosurgery, Beijing Tian Tan Hospital, Capital Medical University, Beijing 100050, China Abstract: Objective We proposed an automatic preoperative path planning method based on diffusion tensor imaging (DTI) for brain stem tumor surgery to effectively circumvent the important organizations and reduce the disability rate. Methods In this paper, DTI and magnetic resonance imaging (MRI) were combined effectively for the automatic preoperative path planning of brain stem tumor surgery. Firstly, DTI was corrected and registered with MRI. Then, the key region information of these two modal images was extracted for automatically designing the surgical path with gravity repulsion model and spline interpolation. Results Our method could complete automatic preoperative path planning through extracting the info