雾化吸入和肌肉注射α1b干扰素治疗手足口病的疗效及安全性比较.docVIP

雾化吸入和肌肉注射a lb干扰素治疗 手足口病的疗效及安全性比较 邓益斌王惠敏余彦林 目的对比分析雾化吸入和肌肉注射a lb干扰素治疗普通手足门病的疗效及安 全性。方法采用随机对照试验方法将150例普通手足口病患儿随机分为雾化吸 入组和肌肉注射组各75例，两组在常规治疗的基础上，雾化吸入组给予(ilb 干扰素雾化吸入，2ug/kg ?次，1日2次;肌肉注射组给予a lb干扰素肌肉注射， 2ug/kg ?次，1日1次，两组的疗程均为5天。比较两组的临床疗效和不良反砬。 结果雾化吸入组的发热持续时间〔(1.68±0.85) vs (2.28±0.97) d］、疱疹消 退时间［(2. 28±1.06) vs (3.05±1.32) d］和口腔疼痛时间［(1.44±0.45) vs (1.75土0.50) d］均短于肌肉注射组,差异有统计学意义(P均〈0.05)。发展为 重症手足口病的比例(4.0%vs2. 7%)两组无统计学差异(c2=0. 207, P0. 05)。 两组均未发现明显的不良反应。结论alb干扰素治疗手足1_1病安全性好，早期 雾化吸入较肌肉注射疗效更好。 关键词： 手足口病;￡ lb干扰素;雾化吸入;肌肉注射; 邓益斌(1973-),男，副主任医师，擅长儿童感染性疾病的诊治。 Analysis the Therapeutic Effect and Safety of Nebulized and Intramuscular Injection of Interferon a lb in the Treatment of Hand-foot-mouth-disease DENG Yi-bin WANG Hui-min YU Yan-lin The Pediatrics ofSi^huanS^ence City Hosoital: Mianyang city tour fairy area Yun Feng township health centers; Abstract： Objective To compare the therapeutic effect and safety of nebulized and intramuscular injection of interferon a 1 b in the treatment of hand-feet-mouth disease (IIFMD) ? Method This was a randomized controlled study. 150 cases of common HEMD were randomly divided into inhalation group and intramuscular injection group, 75 cases in each, two groups on the basis of routine treatment, the inhalation group was treated with nebulization of interferon a 1 b, 2 ug/kg-time, twice each day. Whoever intramuscular injection of interferon a 1 b in muscle injection group, 2 ug/kg-times, 1 times a day, two groups were treated for 5 days. The clinical efficacy and adverse reactions were compared between the two groups. Result The duration of fever[ (1. 68±0. 85) vs (2.28 ±0. 97) D] and the duration of herpes zoster [ (2. 28± 1. 06) vs (3. 05± 1. 32) D] and oral paint (1. 44±0. 45) vs (1. 75±0. 50) D] of inhalation group were shorter than intramuscular injection group, the difference is statistically significant (P0.05) . The two groups were not statistically significant difference between the proportion (4. 0% vs 2. 7%) of development of sev