抗疟药在皮肤科的应用.pdfVIP

Dermatologic Therapy, Vol. 20, 2007, 160–174 Copyright © Blackwell Publishing, Inc., 2007 P rinted in the United States · All rights reserved DERMATOLOGIC THERAPY ISSN 1396-0296 Blackwell Publishing Inc New concepts in antimalarial use and mode of action in dermatology SUNIL KALIA JAN P. DUTZ Department of Dermatology and Skin Science, University of British Columbia, Vancouver, BC ABSTRACT: Although chloroquine, hydroxychloroquine and quinacrine were originally developed for the treatment of malaria, these medications have been used to treat skin disease for over 50 years. Recent clinical data have confirmed the usefulness of these medications for the treatment of lupus erythematosus. Current research has further enhanced our understanding of the pharmacologic mechanisms of action of these drugs involving inhibition of endosomal toll-like receptor (TLR) signaling limiting B cell and dendritic cell activation. With this understanding, the use of these medications in dermatology is broadening. This article highlights the different antimalarials used within dermatology through their pharmacologic properties and mechanism of action, as well as indicating their clinical uses. In addition, contraindications, adverse effects, and possible drug inter- actions of antimalarials are reviewed. KEYWORDS: antimalarial drugs, dermatomyositis, lupus erythematosus, pharmacology, sarcoidosis Introduction resistant to treatment with quinine (5).