[医学]浙江大学医学免疫学经典课件免疫10、12-T细胞.pptVIP

3) memory T cells 1) CD45RA-CD45RO+, 2) Long-lived memory to specific antigen 3) Mediate faster, stronger and more effective immune response 4) Mechanism: low dependent on costimulatory molecules or more sensitivity to cytokines Summary Development of T cells: Markers and stages, Essentials; 2. T cell surface markers: Related to Functions 3. T cell subsets: ?? vs ??; CD4 vs CD8; Ths.. 4. Functions of T cells: Th1, Th2, CTL; 5. Cell-mediated immunity: Activation of T cells Effector of T cells * * * * The thymus is made of lobules, each contains cortical (outer) and medullary (central) regions. The cortex consists of immature thymocytes associated to cortical epithelial cells. The medulla, consists of mature thymocytes. medullary epithelial cells along with macrophages (yellow) and dendritic cells (branched, yellow). * * * * * CD40L主要表达在活化CD4+T细胞、部分CD8+T细胞和?? T细胞,CD40L结合到B细胞表面CD40产生的信号，是B细胞进行免疫应答和淋巴结生发中心形成的重要条件。 * * * * * * Na?ve vs memory T cells ?? vs ?? T cells CD4 vs CD8 T cells T cell differentiation 4. Functions of T cells 1. CD4+ helper T cells (Th): Th0:Th cells that secrete broad spectrum of cytokines at low level. Th1: produce IL-2 and IFN-?, but not IL-4. They are chiefly responsible for cell-mediated immune responses, but can also help B cells to produce IgG2a, but not much IgG1 or IgE; Th2: secrete IL-4, 5, 10, 13, but not IL-2 and IFN-?, are very efficient helper cells for production of antibody, especially of IgG1 and IgE ; Th1 vs Th2 CD4 T cell mediate immunity – effecter functions 2.?CD8+ cytotoxic T cells (CTL) Function: directly kill target cells (cytotoxicity) 1. Cytolysis (necrosis) three stages: a. contact phase: recognition of antigen in the context of MHC class I molecules b. secretory phase: release of cytolytic granules (perforin and granzymes) c. lysis phase: osmotic death CTL Mechanisms ? 2. Cell apoptosis: a. FasL-Fas: CTLs express FasL interaction with