【医学PPT课件】糖尿病的胰岛素治疗.ppt课件.pptVIP

* 这是诺和锐的分子结构图,它是有门冬氨酸替代人胰岛素B28的脯氨酸而形成的生物合成的人胰岛素类似物。 * 单体间接触区域是两个抗平行结构，从B20伸展到B29，结合非常紧密。 速效胰岛素类似物，lispro和aspart，都有B28位的替代。 lispro是将28跟29调换，aspart是将28位脯氨酸替换为门冬氨酸。 两者的替换都导致与人胰岛素相比六聚体的快速解离 The monomer to monomer contact area in the two anti-parallel monomers of the dimer stretches from residue 20 to 29. The fit is very tight. The rapid-acting analogues, lispro and aspart, both have substitutions in B28. Insulin lispro has an inversion of residues B28 and B29. In insulin aspart B28 proline has been substituted by an aspartic acid residue. Both substitutions result in a hexamer that dissociates m