炎症性肠病ibd的肠外表现.ppt

* * * * UDCA a is hydrophilic, non-cytotoxic bile acid, which is normally present in human bile, but in very low concentrations only. It is the major bile acid of the bear. In primary cholangiopathic liver diseases, such as PBC, UDCA protects the injured cholangiocytes by making the bile acid composition of bile hydrophilic. It stimulates biliary secretion and it inhibits bile acid induced apoptosis. Recently, it has been suggested that UDCA may stimulate - via binding to the nuclear receptor SXR/PXR the metabolism of hydrophobic bile acids by cytochrome-P3A4 to hydroxylated, hydrophilic and l