Restoring airway epithelial barrier dysfunction-a new therapeutic challenge in allergic airway disease-外文参考资料.pdfVIP

REVIEW Restoring airway epithelial barrier dysfunction: a new therapeutic challenge in allergic airway disease* 1 1 2 3 Brecht Steelant , Sven F. Seys , Guy Boeckxstaens , Cezmi A. Akdis , Jan L. Rhinology 54: 195-205, 2016 1 1,4,5,6 Ceuppens , Peter W. Hellings DOI:10.4193/Rhino15.376 1 Clinical Immunology, Department of Microbiology and Immunology, KU Leuven, Leuven, Belgium *Received for publication: 2 Translational Research in Gastro Intestinal Disorders, KU Leuven, Leuven, Belgium December 20, 2015 3 Swiss Institute of Allergy and Asthma Research (SIAF), University of Zurich, Davos, Switzerland Accepted: April 18, 2016 4 Clinical Division of Otorhinolaryngology, Head and Neck Surgery, University Hospitals Leuven, Belgium 5 Department of Otorhinolaryngology, University Hospitals Ghent, Belgium 6 Department of Otorhinolaryngology, Academic Medical Center, University of Amsterdam, Amsterdam, the Netherlands Abstract An intact functional mucosal barrier is considered to be crucial for the maintenance of airway homeostasis as it protects the host immune system from exposure to allergens and noxious environmental triggers. Recent data provided evidence for the contri- bution of barrier dysfunction to the development of inflammatory diseases in the airways, skin and gut. A defective barrier has been documented in chronic rhinosinusitis, allergic