【医学课件】 Th1Th2细胞因子在感染中的意义.pptVIP

更多医学精品尽在医学吧;Th1/Th2细胞因子在感染中的意义;细胞因子;;The differentiation of na?ve T cells to Th cells. Depending on the adjuvanticity of the substances co-exposed with the antigen and status of the cells and cytokines in the microenvironment, na?ve T cells can differentiate into Th1, Th2, Th9, Th17, and Th22.?;Role of Th1 and?Th2 cells, and cytokines?in the regulation of cellular and?humoral immunity. ;Th1/Th2 profile in our hospital; The median levels of IL-4, IL-6, IL-10, TNF-a and IFN-r in febrile patients before antibiotic therapy were 3.9, 660.1, 122.7, 6.9 and 11.4 pg/mL, respectively. The interval between the two detections was 5.5 (2–24) days. Returned to 3.3, 22.8, 9.6, 4.1 and 6.4 pg/mL, respectively, after infection was controlled. ;;Between the G+ and G? BacterialSepsis;IL-6, IL-10, and TNF-a levels in patients with G? bacterial infection were higher than those in patients with G+ bacterial infection. The IL-6, IL-10, and TNF-a of G? group were 525.4 (10.2 to 5,000), 96.0 (7.0 to 5,000), and 6.9 (2.5–4263.4) pg/ml, respectively, which were all significantly higher than those of G+ group (150.0 (8.5 to 5000), 22.6 (3.4–2813.7), and 4.5 (2.5–81.6) pg/ml (P0.001), but the IL-2, IL-4, and IFN-r levels were comparable between the two groups (P0.05).;;In Hemophagocytic Lymphohistiocytosis (HLH);In HLH patients, IFN-r and IL-10 levels were significantly elevated and IL-6 levels were moderately elevated, but in MDI patients, IL-6 levels were much higher (usually 1000.0 pg/mL) than in HLH patients (60/145 (41.4%) vs. 2/43 (4.7%); p 0.001); IL-10 levels were highly elevated in patients with HLH and MDI diseases, but the rate in HLH cases (21/43 (48.8%) with high levels of IL-10 (1000.0 pg/mL)) was significantly higher than that (17/145 cases (11.7%); p 0.05) in MDI patients. ;;Between septic shock and non-shock;In septic shock, the IL-2, IL-4, IL-6, IL-10, TNF-a and IFN-r levels were 3.2 (2.3–150.1), 4.7 (2.3–54.9), 2430.6(155.0–5000), 418.9 (27.8–5000), 6.5 (3.3–2140.7