(精选)【医学课件课件】旋毛虫教学课件.pptVIP

Tissue-blood dwelling nemotodes Filaria -cause filariasis Four important filarial worms parasitic in humans are: Wuchereria bancrofti 班氏吴策线虫 Onchocerca volvulus 旋盘尾丝虫 Brugia malayi 马来布鲁线虫 Loa loa 罗阿罗阿线虫 W. bancrofti is strictly a human pathogen and is distributed in tropical areas worldwide More than 80 million were affected Orient, South Pacific, and Southern Asia to India – overlaps with Wuchereria bancrofti - but does not occur in Africa or South America B. malayi infects a number of wild and domestic animals Morphology--Adults of Wuchereria bancrofti Adults occur in the lymphatic vessels （Adult B. malayi are only half the size of W. bancrofti ） filariform larva 丝状蚴 Microfilariae of Wuchereria bancrofti Microfilariae are seen in blood smears and are DIAGNOSTIC worms are 230-320 μm long Morphological differences of microfilariae of Wuchereria bancrofti and Brugia malayi Wuchereria bancrofti Brugia malayi Length 244-296× 5.3-5.7 177-230× 5 -6 (μm) Appearance graceful sweeping Irregular kinky 体态 curves curves Cephalic space length equals width length twice width 头隙 Body nuclei well defined, discrete, blurred, intermingled 体核 round, uniform sized nuclei crowded together Tail no terminal nuclei two terminal nuclei 尾核 Filariform larve--infective stage Microfilariae of Wuchereria bancrofti Nocturnal periodicity of microfilariae 夜现周期性 Pathology of Wuchereria bancrofti Incubation period no symptoms 3 clinical phases: microfilaremia - no symptoms or mild symptoms 微丝蚴血症 Acute allergic inflammatory phase a. lymphadenitis, lymphangitis 淋巴结炎 淋巴管炎 Acute allergic inflammatory phase b. filarial fever 丝虫热 c. funiculitis, orchitis, epididymitis