(精选)Technological Advances in RRT Five Years and Beyond教学课件.pptVIP

WHY A MONOMOLECULAR MEMBRANE? Specific Monomolecular Membranes from Molecular constructs WHY A MONOMOLECULAR MEMBRANE? Short Pore Length Low Pressure WHY A MONOMOLECULAR MEMBRANE? “Zero” Tortuosity Nanomembrane TOPVIEW 0.0025 μm thick Low Pressure WHY A MONOMOLECULAR MEMBRANE? Biocompatibility? Microelectromechanical systems (MEMS)* The Advantages of a Silicon Nanopore Membrane Miniaturization Uniform pore size and shape Reduced hydraulic resistance Inert, non-toxic, biocompatible Fissell WH et al. J Membrane Science 326: 58, 2009 Arrythmia Care as a Paradigm for the 21st Century ? “3Rs of 21st Century” Relocate the site of care from the clinic to the home or the patient’s own body Reduce disposables Rely on automated sensing and control structures to free up health care professionals from role of passive monitors Control of Pore Geometry Narrower pore size distribution = larger mean pore size Large mean pore size = higher hydraulic permeability High hydraulic permeability = no blood pump Pore Size N Hydraulic Permeability Blood Contact with Silicon Membranes Bioartificial Proximal Nephron Hemofilter Blood Blood Urine Proximal Tubule Cells Continuously Functioning Artificial Nephron (CFAN) Artery Vein G-membrane T-membrane Waste High Flux +Selectivity = Small Size CFAN-1 vs. Dialysis (Mathematical Simulation) U.S. 4hr dialysis Japan 5hr dialysis CFAN-1 filtration U.S. 4hr TAC=67.3 mg/dL Japan 5hr TAC=58.0 mg/dL CFAN-1 TAC=26.7 mg/dL TAC Urea Achieved vs. Filtration Time (Mathematical Simulation) B2-Microglobulin TAC (Mathematical Simulation) CFAN Wearable System A Wearable Continuously Functioning Artificial Nephron Design Concept Recent Progress Synthesis of pores for in vitro testing Fabrication of membrane with pores Scale-up methodology in final stages of development Key Collaborators Martin Edelstein, PhD, Co-founder Biophiltre, LLC Chemistry; instrumentation; software; pharmaceutical development; qual