(精编)【医学课件】 Pseudomonas aeruginosa biofilm formation教学课件.pptVIP

Stages in the pathogenesis of N. gonorrhoeae Gonococcal urethritis in male patients and, less frequently, epididymitis Recombinant conversion of the pilE locus as a mechanism of antigenic variation Chromosomal organization of pilin genes in Neisseria gonorrhoea Gonorrhea in women Asymptomatic with cervicitis, urethritis Cervicitis with abnormal vaginal discharge, inter-menstrual bleeding, dysuria, lower abdominal pain or dyspareunia (painful intercourse) Accessory gland infections (Bartholin’s or Skene’s gland) Pelvic Inflammatory Disease (PID): asymptomatic, lower abdominal pain, discharge, dyspareunia, irregular menstrual bleeding and fever Fitz-Hugh-Curtis Syndrome (perihepatitis) Infertility Tubular pregnancy Fitz-Hugh-Curtis Syndrome Neisseria gonorrhoeae, cervicitis and inflammation of the bartholini’s gland Neisseria gonorrhoeae, cutaneous lesions following urethritis and conjuctivits Neisseria gonorrhoeae, ophthalmitis in a newborn Extragenital gonorrhea in men and women Anorectal infection acquired by anal intercourse Usually asymptomatic Symptoms: anal irritation, painful defecation, constipation, scant rectal bleeding, painless mucopurulent discharge, tenesmus, and anal pruritus Signs: mucosa may appear normal, or purulent discharge, erythema, or easily induced bleeding may be observed with anoscopic exam Pharyngeal infection May be sole site of infection if oral-genital contact is the only exposure Most often asymptomatic, but symptoms, if present, may include pharyngitis, tonsillitis, fever, and cervical adenitis Extragenital gonorrhea in men and women (continued) Conjunctivitis Usually a result of autoinoculation in adults Symptoms/signs: eye irritation with purulent conjunctival exudate Disseminated gonococcal infection (DGI) Systemic gonococcal infection Occurs infrequently. More common in women than in men Associated with a gonococcal strain that produces bacteremia without associated urogenital symptoms Clinical manifestations: skin lesio