(精编)【医学课件】 Schizophrenia and other psychotic disorders教学课件.pptVIP

Neurotransmitters in schizophrenia- dopamine Drugs that increase dopamine (agonists), result in schizophrenic-like behavior Drugs that decrease dopamine (antagonists), reduce schizophrenic-like behavior /pharmwiki/doku.php/rx_of_schizophrenia Neurotransmitters in schizophrenia /article/10.3389/fendo.2015.00090/full /files/Articles/50246/fncel-07-00111-HTML/image_m/fncel-07-00111-g001.jpg Course of schizophrenia Prenatal 0-10years 10-18y 18-25y 25y Louis Wain - a schizofrenic painter known for his cat pictures. These ones show his deteriorating mental health over time. Treatment of schizophrenia 1 Pharmacological Antipsychotics: main act: D2 antagonist Pill, solution or short time acting im.injection 1st generation or typical: i.e haloperidol, tiapride 2nd generations or atypical: i.e.: riperidone, olanzapine, quetiapine, clozapine, amisulpirid, aripiprazol (D2 parcial agonist) Side effects: extrapiramidal (dystonia, akathisia, tremor, tardive dyskinesia) weight gain, sexual dysfunction, sedation, hypotonia, obstipation, accomodation problem (vision) Depot injections: acting for 2-4weeks, im. inj. :olanzapine, riperidone, paliperidone, aripiprazol, haloperidol Schizophrenia and other psychotic disorders Beatrix Mersich M.D., Ph.D. Semmelweis University Department of Psychiatry and Psychotherapy 26/Sept/2016 Outline History Terminology Symptoms - Diagnosis Epidemiology Etiology Pathophisiology Treatment Other psychotic disorders Schizophrenia Schizophrenia – history 1 Before the XIXth century: irrational behaviour was explained mostly by religious beliefs. Treatment was isolation ~ ship of fools Emil Kraepelin (1856-1926) german psychiatrist: ?dementia praecox”– loss of cognitive functions at young age Distinguished from mood disorders Eugen Bleuler (1857-1939) swiss psychiatrist :?the separation of function between?personality,?thinking,?memory, and?perception the word comes from the?gre