Efficacy and Acceptability of Hydroxypropyl Cellulose ：羟丙基纤维素的疗效和可接受性.pptVIP

Bruce H. Koffler, MD University of Kentucky School of Medicine The author of this poster has received research funding and travel expense reimbursement from Aton Pharma. The author would like to acknowledge Susan Terner, MS , and Donald Nelinson , PhD, for support in preparation of the poster with funding from Aton Pharma. Efficacy and Acceptability of Hydroxypropyl Cellulose Ophthalmic Inserts: Subsets of Patients With Dry Eye Syndrome in a Patient Registry For interactivity go to View and click Slide Show Purpose:?To determine efficacy and acceptability of hydroxypropyl cellulose ophthalmic inserts (HCOI) in subsets of patients with dry eye syndrome (DES). Methods:?A multicenter, open-label, prospective registry enrolled 520 patients with bilateral moderate-to-severe DES.?Clinical examinations and Patient Questionnaires incorporating the OSDI assessed clinical signs, average symptom severity and frequency, limitations in ADL, and ocular discomfort in various environments 1 month before baseline and 1 month of treatment. Inserts were used alone or with existing therapy.? Results:?There were 418 completers.?OSDI scores improved significantly (P.05) in contact lens (23.2%), prior cataract surgery (29.2%), and prior refractive surgery (19.5%) subgroups.?OSDI improvement was not significant in cataracts or glaucoma groups.?Discomfort, burning, dryness, grittiness, stinging, and sensitivity to light were significantly reduced (P.05) for cataracts, and discomfort and dryness improved significantly (P.05) for glaucoma.?Blurred vision was the most commonly reported AE. Conclusions:?After 1 month, HCOI as monotherapy or with existing therapy improved symptoms, ADL performance, and quality of life in moderate-to-severe DES subsets. ? Abstract Introduction Patient subsets Contact lens1 factors affecting DES Characteristics of lenses Protein, lipid and mucin deposits Intolerance of lens solutions Surgery increases risk of DES, depending on type of procedure Cataract surge