a3制剂中大腹皮等质量控制与优化分析 word格式.docx

etherextractionofpericarpiumarecae.17compoundswereobtainedfromthispart,andtheirstructurewereidentifiedbyIR,URand MS, 1H-HMR,13C-HMR.Andtheywere:hexadecanoicacid,betasitosterolandsoonDefinitedthechemicalcompositionofpetroleumetherextractionof pericarpiumarecae.Forthefirsttime,studiedonthechemicalconstituentfrompetroleumetherextractionofpericarpiumarecabyGasChromatography-MassSpectrometry,andestablishedGC-MSfingerprintingofpetroleumetherextractionoftensamplesofpericarpiumarecaandevaluationmethodbyGC-MS.andestablishedascientificand feasiblequalityevaluationsystemofpericarpiumarecaebasedonmultipleindex.Providtheoreticalbasisforqualityevaluatingsysteminmedicalmaterialplanting、purchasing,productionofChineseformulatedproducts.Basedonthestudyof46kindsofpurplecommonperillasamplesinthewholecountry,foundthateffective constituents content difference fromdifferentoriginisverygreat.Therefore,systemlyscreenedthebreedvarietyofpurplecommonperilla,plantingbase,harvesttime,processingmethod,abstractiontechnology,andestablishedqualitycriteriaandfingerprintingmethod.Thefueloilwasblendedintoeffectivecomponentwithstablequality,volatileoilswasincluedbyhydroxypropyl-betacyclodextrin.Studyonthelong-termstabilityandacceleratethestabilitytestingshowedthattheoilhydroxypropyl-β-cyclodextrininclusioncompoundcanincreasethestabilityofeffectiveingredientsandreducethedegradationrate.ApplicatedtheBox-Behnkendesign-effectsurfacemethodtooptimizepreparationprocessofperillartinehydroxypropyl-β-cyclodextrininclusioncompoundfirsttime,usedmolecularsimulationtechnologytostudywithinclusionprinciple.Studiedtheinclusioncompoundstructurebytheinfraredspectrophotometry,X-ray,1H-NMR,DSC-TG test, the results showed that the experiment can be inaccordancewiththedesignedscheme.Basedonthesystemlystudyofpericarpiumarecae,perillartine,establishedanresearchmodelofotheringredientsinA3prescriptionandinternalenterprisestandards.Improvedtheproductionprocess,qualitycontrol,qualityandtherapeuticeffect,andmadetheproductissafeand