不同精制工艺对黄芩水提液物理化学参数及生物药剂学特性影响-中药学专业论文 word格式.docxVIP

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不同精制工艺对黄芩水提液物理化学参数及生物药剂学特性影响-中药学专业论文 word格式.docx

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不同精制工艺对黄芩水提液物理化学参数及生物药剂学特性影响-中药学专业论文 word格式

Abdominal aorta. Blood drug concentration was determined by HPLC method and the plasma concentration-time curve was drawed. Calculating the pharmacokinetic parameters.Results 1. The optimum aqueous extraction process of the Scutellaria baicalensis were extracting 65 minand 3 times, 10 times the amount of added water. 2. To refined alcohol sedimentation with 70% alcohol content of the aqueous extraction of Scutellaria baicalensis, the optimum process of chitosan flocculation were as follows: the value ofpH was 5 and the flocculation temperature was 50℃,the chitosan dosage was 0.5mL/g. 3.By 20000r/min high-speed centrifugation pretreatment, The optimum aqueous extraction process of ceramic membrane microfiltration were the system temperature 30℃, 0.08MPa filter differential pressure, 4.2m3/h flow rate of feed. 4. The plasma concentration-timecurve of baicalin shows the existence of double peaks. 5. Through the study of the three kinds of refining process, the ceramic membrane microfiltration was the optimum refining process of the aqueous extraction of Scutellaria baicalensis, it’s transport rate of baicalin of was the maximum and the value of conductivity, turbidity, viscosity and non-medical polymer material was the lowest, the baicalin of bioavailability was the highest.Conclusion Box-Behnken design is suitable for optimizing the aqueous extraction technique of the Scutellaria baicalensis; And the optimum refined technology of the aqueous extraction of Scutellaria baicalensis was the ceramic membrane microfiltration. The absorption of baicalin in rats and the physics and chemistry parameters have certain relativity. To explore the feasibility for the evaluation system of the physical and chemical parameters of the herbal extracts.Keywords The aqueous extraction of Scutellaria baicalensis; Refining technology; Physical and chemical parameters; BiophamaceuticsAuthor: Xierong Tutor: Tangzhishu目录引言 .............................................................. 1正文 ....