生署疾病管制局.pdfVIP

Prions (CJD) and Processing of Reusable Medical Products 生署 疾病管制局 中區傳染病防治醫療網 王任賢 指揮官 Copyright 2004 WA Rutala Prions and Processing of Reusable Medical Products Topics l Rationale for United States recommendations nEpidemiological studies of prion transmission nInfectivity of human tissues nEfficacy of removing microbes by cleaning nPrion inactivation studies nRisk associated with instruments l Recommendations to prevent cross-transmission from medical devices contaminated with prions Copyright 2004 WA Rutala Transmissible Spongiform Encephalopathies (TSEs) of Humans lKuru lGertsmann-Straussler-Scheinker (GSS) lFatal Familial Insomnia (FFI) lCreutzfeldt-Jakob Disease (CJD) lVariant CJD (vCJD), 1995 Copyright 2004 WA Rutala CJD Copyright 2004 WA Rutala Prions and Processing of Reusable Medical Products l Rationale for US recommendations nEpidemiological studies of prion transmission nEpidemiological studies of prion transmission via surgical instruments nInfectivity of human tissues nEfficacy of removing microbes by cleaning nPrion inactivation studies nRisk associated with instruments Copyright 2004 WA Rutala Transmissibility of Prions lTransmission n Not spread by contact (direct, indirect, droplet) or airborne n Not spread by the environment n Experimentally-all TSEs are transmissible to animals, including the inherited forms n Epidemiology of CJD: sporadic-85%; familial-15%; iatrogenic- 1% (primarily transplant of high risk tissues, ~250 cases