tissues引起细胞损伤的.pdf

Inflammation • The stimuli that cause cell injury also elicit a complex inflammatory reaction designed to (1) eliminate the cause of injury and (2) clean up the dead and the dying cells and tissues. 1 2 Inflammation and Repair • •Inflammation accomplishes its missions by trying to dilute, destroy or otherwise neutralize the offending agents. • •The inflammatory response is followed by a set of repair processes designed to regenerate the damaged tissue and/or fill the gaps with fibrous tissue (scar). • •Both the initial inflammatory reaction and the subsequent repair reactions can potentially cause harm. • Components of the Inflammatory Response Basic Patterns of Inflammation • •Acute inflammationis of relatively short duration (hours to days) and is primarily characterized by exudation of fluid and plasma proteins, as well as a neutrophilicinfiltration. • •Chronic inflammationis of longer duration (days to years) and is characterized by mononuclear infiltration, vascular proliferation and scarring. • In practice, these two patterns of inflammation often overlap. Patterns of Inflammation Normal Gastric Corpus Acute Inflammation • •Acute inflammation has two major components: • 1.Vascular component • 2.Cellular (leukocytes) component • • 1. • 2. • •Which result in the classic clinical triad of: •