赵仑_09_March_ERP高级培训班讲座(4).pptVIP

ERP时频分析 Basar 等（1984，1985） time-frequency analysis Band Analysis Evoked－time-phase locked Induced－time-, non-phase locked ERD/ERS Event-related desynchronization Event-related synchronization Coherence Analysis ….. Neurophysiology must develop new ways to measure the activity of networks. This will probably involve correlational studies and attention to rhythms as well as to isolated potentials. ----- Picton, Alain, McIntosh VEP-2D frequency VEP-2D VEP-3D 脑电地形图 源分析 偶极子（Dipole） 是一对数值相等、符号相反的电荷，彼此相隔一定距离时形成的体系。 ERPs成份的源 即脑内的偶极子。神经传导递质作用于突触后神经元受体的过程中产生的突触后电位导致了ERPs的产生(Luck,1998)。头皮电位的分布取决于电流偶极子的位置与方向。 源定位 可根据偶极子的数目、时间特征、位置和偶极子量等因素推导。 偶极子模型－single/multiple dipole models 偶极子定位 电流密度（current density）可看作一定容积内的偶极子量 每个偶极子代表一定容积的电流密度,偶极子量与所代表的电流密度是成比例的。 电流密度 ERP溯源分析的相关问题 怎样确定用于溯源分析的时间范围？ 如何有效地使用PCA/ICA？ 什么情况下需要将某些ICA成分滤除？ 对自己的数据，应该选择哪一种源重构模型最适当？ 如何判断得到的溯源结果是否真实？ Auditory-Visual Speech Integration McGurk Effect by Source Reconstruction Auditory /ba/ Reconstruction Time Points (for each identified peak in the mGFP) Visual /ba/ Auditory Visual /ba/ 70 ms 165 ms 150 ms 204 ms 90 ms 212 ms Auditory /ba/ Current Density Reconstruction (Minimum Norm Least Squares) Visual /ba/ Auditory Visual /ba/ Latency - 70 ms (auditory PI) Auditory /ba/ Current Density Reconstruction (Minimum Norm Least Squares) Visual /ba/ Auditory Visual /ba/ Latency - 150 ms (visual PI) Why is SNR Important? What is SNR? Signal-noise-ratio (many options for calculation) Where do I find it? Transforms Why is it important? Tendency to overestimate peak amplitude e.g., If SNR is 2:1, as much as half measure amplitude may reflect noise. Problem enhance by using extremes as peaks. example: ms -100.0 -50.0 0.0 50.0 100.0 150.0 200.0 250.0 300.0 350.0 3 μV Electrode Cz 4.2 μV p.p. 5.3 μV p.p. 25% increase in measure amplitude DUE TO NOISE CONCLUSIONS Confidence Ellipsoids Description of error/variability rel