花刺柳珊瑚echinogorgia flora化学成分及生物活性分析word格式论文.docx

物进行了抗病毒活性测试。结果表明，分离得到的愈创木烷型倍半萜类化合物对肿瘤细胞基本没有抑制活性；化合物（1，2，5，8，9，13）显示弱的抗流感病毒活性！关键词：花刺柳珊瑚；化学成分；生物活性Studies on Chemical Constituents and Bioactivities of the Gorgonian Echinogorgia floraAbstractThe genus Echinogorgia is a sessile animal of the Family Paramuriceidae, Order Gorgonacea, Subclass Octocorallia, Class Actinozoa, Phylum Cnidaria. This genus contains about 30 species, widely distributed in the southwest of Pacific Ocean and the South China Sea. Studies on chemical constituents of this genus began in the late 1980s and the secondary metabolites found mainly polyhydroxy sterols as well as few other novel structure types of sesquiterpenes and alkaloids, which showed rich chemical diversity and potential research value of marine natural products. In oder to search for natural products with unique structural features and unprecedented biological activities, we have performed a comprehensive investigation on the chemical constituents and biological activities of the Echinogorgia flora collected from weizhou islands in the South China Sea, in October, 2010.By biological activity-oriented isolation, the MeOH extract of the Echinogorgia flora was chromatographed on TLC, silica gel, and LH-20 Sephadex, and semi - preparative HPLC, respectively. Then forty-one compounds were isolated and purified from the Echinogorgia flora, among wich thirty-eight compounds were identified by means of spectral methods (UV, IR, MS, NMR, CD, et al.) and their physicochemical properties. Among them there are thirteen guaiane-type sesquiterpenes (2~6, 7~14); fourteen sterols (5~28); one polyketide (29); one ceramide (30); two glycerol ethers(31~32); one benzene derivative (33); six alkaloids (1、34~38). What is remarkable is thata new carbon skeleton guaipyridine sesquiterpene alkaloid and five new guaiane-type sesquiterpenes (2~6) was obtained. The known compounds (7~33) were first isolated from the Echinogorgia flora and compounds (8~10, 12~25, 27~28) were first found fr