基于多臂星状聚合物的稳定囊泡的制备及应用分析-preparation and application analysis of stable vesicles based on multi-arm star polymer.docxVIP

ABSTRACTIn this article, the terminal hydroxyl groups of amphiphilic multiarm star copolymers with a hydrophilic hyperbranched polyethylenimine (PEI) core and hydrophobic poly(?-caprolactone) (PCL) arms were partially or completely transformed into the radical-crosslinkable methacrylate (MA) groups (PEI-b-PCL-MA).The resulting PEI-b-PCL-MA polymers with 100% MA substitution self-assembled in water into simple vesicles, whereas those with partial MA substitution aggregated into complex vesicles. These structures could be proved by transmission electron microscopy and dynamic light scattering only after crosslinking the intra-vesicular MA groups that generated the covalently stabilized vesicles (CSVs). A and it was found that the corona of the vesicles was not the simple double-layer structure, but contained a certain amount of star polymeric units between the double-layers.The obtained CSVs could be used as host for the formation of gold nanoparticle (AuNP) cluster, and the AuNP clusters stabilized by the CSVs were stable under a wider range of CSV/AuNP feed ratio than those stabilized by the uncrosslinkedprecursors. The diameter of AuNPs in the clusters was in the range of 4–6 nm, andthe distance of adjacent AuNPs could be modulated through altering the feed ratio of CSV/AuNP. The color of the solutions of AuNPs with CSV could be tuned from brown to red, purple, even blue. The composites of CSV and AuNPs could be further used as nanocarriers to accommodate hydrophobic guest of pyrene, and a higher amount of AuNPs in the nanocarriers led to a lower encapsulation capacity for pyrene guests.Key words: multiarm star copolymers; self-assemble; covalently stabilized vesicles; gold nanoparticle; nanocarrier目录第一章绪论............................................................................................................11.1 多臂星状聚合物 ..................................................................................................11.1.1 多臂星状聚合物的基本概念..........................