茶苯海明口腔崩解片的口味评价与预测.pdfVIP

1 1* 2 3 4 张鹏威 , 高文远 , 王春龙, 苏文琴 , 张彤云 ( 1. , 300072; 21 , 300193; 31, 300401; 41 , 300475) : 评价和预测茶苯海明口腔崩解片的口味 测定茶苯海明的苦 味阈值, 并以自制溶出池测定口腔崩解片 - 1 内药物在人工唾液内的溶出速度, 预测和评价制剂的苦 味 茶苯海明的苦 味阈值为 125~ 750 m g# L , 未掩味与 掩味口腔崩解片内药物在流动溶出池中溶出液的最大质量浓度分别是 1133和 01 10 1m g# L- 1药物浓度越大, 志愿者感受 的苦 味越浓 流动溶出池法可以用于评价和预测茶苯海明口腔崩解片的口味 : 茶苯海明; 口腔崩解片; 掩味 : R944 : A : 1001- 2494( 2008) 04- 0288- 03 Study on Taste Evaluation and Prediction of D im enhydrinate O rally D isintegrating Tablets 1 1* 2 3 4 ZHANG Peng-w ei, GAO W en-yuan , WANG Chun-long , SU W en-qin , ZHANG Tong-yun ( 11School of P harmaceu- ticalScience and Technology, T ianj in University, Tianjin 300072, Ch ina; 21T ianj in Institute of Pharmaceutical Research, Tianjin 300193, Ch ina; 31 6th ChineseM edicine actory, T ianj in Zhongxin Pharmaceutical Co1 L td1, Tianjin 300401, China; 41 Darentang Pharmaceutical actory, Tianjin Zhongxin Pharmaceutical Co1 L td1, Tianjin 300475, Ch ina) AB STRACT: OBJECT VE T o evaluate and predi t the taste of dmi enhydrinate orally d is integrating tablets1 M ETHODS T o de- term ine the taste threshold and the dissolution rate of the drug in the smi ulated salivaw ith a self-m ade dissolution pool1 RE SULTS The taste threshold of dmi enhydrinate was 125~ 750 mg# L- 1 1 Them axmi um on entration of dmi enhydrinate in the dissolu tion solu- tion of tab lets w ith unm asked drug and w ith taste-m asked drug w as 1133 and 01101m g# L- 1 respe tively1 H igher on entration of d-i m enhydrinate in the d issolution solu tion w as asso iated w ith stronger taste of b itterness of the drug1 CONCLUS ON The m ethod of flow-through dissolution ell an be used for evaluation and