il审审6基因启动子区多态性与静脉血栓栓塞症相关性研究-study on the relationship between polymorphism of promoter region of il - 6 gene and venous thromboembolism.docxVIP

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il审审6基因启动子区多态性与静脉血栓栓塞症相关性研究-study on the relationship between polymorphism of promoter region of il - 6 gene and venous thromboembolism.docx

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il审审6基因启动子区多态性与静脉血栓栓塞症相关性研究-study on the relationship between polymorphism of promoter region of il - 6 gene and venous thromboembolism

frequency of each group. x ±s was used to indicate the measurement data, rank-sum test and t test to comparing the two groups of means and X2 test the count data. Correlation analysis use Spearman rank correlation analysis. Results: Firstly, there was significantdifferences in TNF-a、IL-6、PLT、WBC、heart rate、BMI、creatinine、FIB、D-D betweenVTE group and control group(P0.05). Secondly, level of TNF-a、IL-6 and CRP was significantly higher in VTE group than control group(P0.05). Thirdly, the -597G/A promoter polymorphisms of the IL-6 gene has GG and GA genotypes. The gene frequency of the -597G/A promoter polymorphisms was GG[23(8.55%)] and GA[246(91.45%)]. There was no significant difference the -597G/A promoter polymorphisms between VTEgroup and control group. The -572G/C promoter polymorphisms of the IL-6 gene has GG、GC and CC genotypes. The gene frequency of the -572G/C promoter polymorphisms was CC[74(27.5%)], GG[31(11.5%)] and CG[174(64.7%)]. There was significant difference in the -572G/C promoter polymorphisms between VTE group and control group(P0.05). There was significant difference in the allele frequency of the nationality and sex in VTE group(P0.05). There was significant difference in neutrophilic leukocyte among different genotypes. The result of the correlation analysis shows that there was a correlation between neutrophilic leukocyte and genotypes. Incidence rate of thrombus in inflammation group is higher than no inflammation group. Conclusions:The inflammation is closely related with VTE. The increase of inflammation factor maybe a predictor relating to VTE pathogenesis and a important risk factor. The inflammation factors promotes blood clotting through enhancing and increasing blood coagulation factors. It maybe one of VTE pathogenesises. There maybe a correlation between the -572G/C promoter polymorphisms of the IL-6 gene and the affectivity of VTE pathogenesises.There is a close correlation between the TC 、 HDL-C and the -572G/C promote