进行性斑状色素减少症的临床及实验分析-clinical and experimental analysis of progressive macular pigment reduction.docx

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进行性斑状色素减少症的临床及实验分析-clinical and experimental analysis of progressive macular pigment reduction.docx

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进行性斑状色素减少症的临床及实验分析-clinical and experimental analysis of progressive macular pigment reduction

significance(P0.05);TRP-1stainingshowedthebasallayerpositivecellsinlesionareas(4.25±0.96)comparewiththesurroundingnormalskin(4.50±1.29)alsohavenostatisticalsignificance(P0.05).UltrastructuralstudiesshowedalargereductioninthenumberoftypeIVmelanosomefromPMHlesions,andobservedthemajorofmembraneboundgroups,itcontainsanumberofsmallertypeII-IVmelanosomewhichisclusteredllydistributed.Melanocyetescultureissuccessful,anditsmorphologycomparedwithnormalmelanocyteshasnoobviousabnormality.Conclusion:Accordingtoourclinicalandexperimentalstudies,wediscussedandsummarizedthePMH’sclinicaldiagnosticcriteria.(1)usuallyoccurinyoungeradults,nofamilyhistory;(2)Thelesions’characteristicsareilldefinednummular,hypopigmented,nonscalymacules,nohyperpigmentedborderaroundtheachromicareaandnoparesthesia;(3)mainlyoccuronthefrontandbackofthetruck,withconfluenceofthemaculesinandaroundthemidline,andoccasionallyontheneck,extremitiesproximaletc;(4)ThelesionsofPMHshowtheredfollicularfluorescenceunderWood’slamp,andtheConfocalLaserScanningMicroscopyexaminationofthelesionshowthatthe‘pigmentedring’showcompleted,butcomparedwiththesurroundingnormalskinitsmelanincontentwasdecreased;(5)Thebacterialcultivationfromthelesionsarepropionibacteriumacnes,andthethemicroscopicexamandcultureofpatientsforfungusevaluationwerenegative;(6)noorslightdecreaseinmelanocytesnumberintheaffectedareaswhenexaminedhistologically;(7)themajormembraneboundgroupsoflesionsandthenormalappearanceskinoflesionmarginunderelectronmicroscopy.BenzoylperoxidecombinedwithNB-UVBmaybeaneweffectivemethodoftreatmentforprogressivemacularhypomelanosis.shortenedNB-UVBphototherapyperiod,maybeaneweffectivemethodoftreatment【Keyword】Progressivemacularhypomelanosis；pathogenicbacterium；melanocytes；menlanosome英文缩略词表缩写词中文名称英文名称PMH进行性斑状色素减少症progressivemacularhypomelanosisSPSS社会科学统计软件包StatisticsPackageforSocialScienceNB-UVB窄谱中波紫外线NarrowbandultravioletBT311酪氨酸酶抗体Tyrosinase(T311)AntibodyTRP-1酪氨酸相关蛋白-1Tyrosinase-relatedProtein1MelanA黑色素抗体MelanomaAntibodyCLSM皮肤共聚焦激光扫描显微