联合检测her-2和ca125水平在子宫内膜癌诊断及治疗中的临床价值-clinical value of combined detection of her - 2 and ca 125 levels in the diagnosis and treatment of endometrial carcinoma.docxVIP

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联合检测her-2和ca125水平在子宫内膜癌诊断及治疗中的临床价值-clinical value of combined detection of her - 2 and ca 125 levels in the diagnosis and treatment of endometrial carcinoma.docx

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联合检测her-2和ca125水平在子宫内膜癌诊断及治疗中的临床价值-clinical value of combined detection of her - 2 and ca 125 levels in the diagnosis and treatment of endometrial carcinoma

The Clinical Value of Joint Detection of HER-2 and CA125 Level in Diagnosis and Treatment of Endometrial CancerAbstractObjective To analyze the expression of HER-2 and the level of preoperative serum CA125 in Endometrial Cancer（EC）,to set forth the clinical significance of the two abovefor the treatment and prognosis of endometrial cancer.Methods 250 cases are selected from patients who were diagnosed during the first surgical treatment as endometrial carcinoma, which the pathologic result also verified from January 2010 to December 2013 in the Affiliated Hospital of Qingdao university. The pathological specimens were all given HER-2 immunohistochemical detection. 210 cases were given preoperative serum detection. The relationship is analyzed between the expression of HER-2 and the level of preoperative serum CA125 and the age of developing endometrial cancer, histologic classification, muscular infiltration, surgical pathology staging, peritoneal cytology detection, lymph node metastasis, vascular tumor emboli, the pathologic types and relapse. Meanwhile, the correlation of the two is analyzed.Results 1.The positive rate of expression of HER-2 in endometrial cancer is 23.20%, which is related to the age of developing endometrial cancer（P＝0.014), peritoneal cytology detection and vascular cancer stoppers（ P＝0.025）.The differences havestatistical significance.The positive rate of preoperative serum CA125 of endometrial cancer is 25.24%（≥35U／ml）. It has significant connection with myometrial invasive depth（P＜0.001）, surgical pathology staging rise（P＜0.001）, vascular tumor embol（iand peritoneal cytology detection（P＝0.047）.P＜0.001）The relapse rate of the 250 cases is 10. 80%. It is related to the age＜50 of developing endometrial cancer（P＝0.012), histologic classification rise（P＝0.003）, myometrial invasive depth（P=0.046）, surgical pathology staging rise（P＜0.001）,vascular tumor embol（iP =0.010）, vascular cancer stopper（sP＝0.041）and the pathologictypes（P＝0.009）.it is a