联合检测血清和胸水中多项肿瘤标志物对良恶性胸水鉴别诊断价值.docVIP

联合检测血清和胸水中多项肿瘤标志物对良恶性胸水鉴别诊断价值 　　[摘要] 目的：探讨联合检测血清、胸水（胸腔积液）中人组织多肽特异性抗原（TPS）、可溶性肿瘤坏死因子受体（sTNFR）、恶性肿瘤生长因子（TSGF）、癌胚抗原（CEA）、神经元特异性烯醇化酶（NSE）、细胞角质蛋白19片断（CYFRA21-1）对良恶性胸腔积液的鉴别诊断价值。方法：79例临床已确诊的胸腔积液患者（恶性47例，结核性32例）的血清和胸腔积液采用酶免疫法进行TPS、sTNFR、TSGF、CEA、NSE、CYFRA21-1含量测定。结果：恶性胸腔积液患者的6种肿瘤标志物水平均明显高于良性疾病组，差异有统计学意义（P 　　[关键词] 组织多肽特异性抗原；可溶性肿瘤坏死因子受体；恶性肿瘤生长因子；癌胚抗原；神经元特异性烯醇化酶；细胞角质蛋白19片断；结核性胸腔积液；恶性胸腔积液 　　[中图分类号] R561 [文献标识码] B [文章编号] 1673-7210（2011）07（a）-090-03 　　 　　Differential diagnostic value of joint determination of multiple indices in serum and pleural effusion between benign and m alignant pleural exudates 　　CEN Hui1, Li Guanqiang2, LI Wen3, ZHOU Ailian4, ZHANG Weizhen5, XU Ruihuan6 　　1.Department of Respiratory Disease, the Peoples Hospital of Longgang District, Gunagdong Province, Shenzhen 518172, China; 2.Department of Clinical Laboratory, the Peoples Hospital of Longgang District, Gunagdong Province, Shenzhen 518172, China; 3.Department of Respiratory Disease, Affiliated Hospital of Guangdong Medical College, Gunagdong Province, Zhanjiang 524001, China; 4.Department of Respiratory Disease, the Fifth Peoples Hospital of Shenzhen City, Gunagdong Province, Shenzhen 518001, China; 5. Department of Respiratory Disease, Nanfang Hospital, Gunagdong Province, Guangzhou 510000, China; 6 Department of Clinical Laboratory, the Center Hospital of Longgang, Gunagdong Province, Shenzhen 518116, China. 　　[Abstract] Objective: To determine the differential diagnostic value of joint determination of multiple indices, including TPS, sTNFR, TSGF, CEA, NSE, CYFRA21-1, in serum and pleural effusion between benign and m alignant pleural exudates. Methods: 79 patients with pleural effusion included 47 patients with m alignant pleural effusion (m alignant group) and 32 patients with tuberculous pleural effusion (tuberculous group). The level of TPS, sTNFR, TSGF, CEA, NSE, CYFRA21-1 were detected by terminal reaction of enzymology. Results: The level of TPS, sTNFR, TSGF, CEA, NSE, CYFRA21-1 in m a