帕瑞昔布钠在全麻围拔管期临床应用观察.docVIP

帕瑞昔布钠在全麻围拔管期临床应用观察 　　摘 要 目的：观察帕瑞昔布钠在全麻围拔管期对心血管反应以及对术后躁动的影响。方法：选择ASA Ⅰ～Ⅱ行上腹部、四肢躯干手术的全麻患者60例，随机分成两组。观察组(A组)30例，在手术结束前20分钟，静脉推注帕瑞昔布钠40mg。对照组30例(B组)，静脉推注生理盐水10ml。观察围拔管期的心血管反应，患者有无躁动、呛咳、恶心、呕吐,记录诱导前、手术结束时、拔管时、拔管后5分钟及拔管后10分钟两组收缩(SBP)、舒张压(DBP)、心率(HR)、血氧饱和度(SpO?2)，同时记录手术结束到拔管的时间，患者躁动及恶心呕吐的发生情况。结果：在拔管时A、B两组的HR、SBP均较诱导前升高(?P?＜0.05)，而以B组升高明显(?P?＜0.01)；拔管后5、10分钟的HR、SBP仍未恢复到术前(?P?＜0.05)。两组术毕至拔管的时间比较无统计学意义(?P?＞0.05)，A组术后躁动的发生例数明显少于B组，差异有统计学意义(?P?＜0.05),A组恶心呕吐的发生例数也少于B组，差异无统计学意义(?P?＞0.05)。结论：帕瑞昔布钠用于全麻围拔管期能够有效的抑制心血管应激的升高，减少术后患者的躁动，应用于全麻围拔管期是安全有效的。? 　　关键词 帕瑞昔布钠 全麻拔管期 心血管反应 术后躁动? 　　doi:10.3969/j.issn.1007-614x.2012.06.197?? 　　Abstract Objective:To observe the Chapa Rui celebrex sodium anesthesia on the cardiovascular response to tracheal extubation period and the impact of postoperative agitation.Methods:ASA Ⅰ～Ⅱ line on the abdomen,limbs,trunk anesthesia in surgery 60 patients were randomly divided into two groups,the observation group (A group of 30 patients,parecoxib sodium group),control group (B group of 30 patients,physical saline group),20 minutes before the end of surgery,A group of intravenous injection of 40mg parecoxib sodium,B group intravenous injection of 10ml of normal saline,observation period,the cardiovascular response to tracheal extubation,patients with or without agitation,cough,nausea,vomiting,record before induction,the end of surgery,extubation,after extubation and 5min 10min after extubation patients were contraction(SBP),diastolic blood pressure(DBP),heart rate (HR),oxygen saturation (SpO?2) while recording the end of surgery to extubation time in patients with agitation and the incidence of nausea and vomiting.Result:in extubation A,B groups of HR,SBP increased compared with before induction(?P?＜0.05),while Group B increased significantly(?P?＜0.01);extubation after 5min,10min of HR,SBP is still did not recover to the preoperative(?P?＜0.05);two hours of surgery to extubation was not statistically significant(?P?＞0.05),A the incidence of postoperative agit