肝素连接苯丙氨酸血液净化材料去除内毒素的分析-analysis of removing endotoxin from heparin - linked phenylalanine blood purification material.docxVIP
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肝素连接苯丙氨酸血液净化材料去除内毒素的分析-analysis of removing endotoxin from heparin - linked phenylalanine blood purification material
heparinandaminationchlorineresin.(4)Theadsorptionequilibriumcanbereachedinlessthantwohours,and90%ofthemaximumadsorptioncapacitywasreachedonlyunder1hour,whiletheremovalrateinplasmacanbeup70%.(5)Afterperfusedsimulationexperiment,thebloodcellsandplasmaproteinchangeswerelessthan5%and10%,whichmeansagoodbloodcompatibility.Conclusion:Chloromethylresinactsasbasematerial,heparinaslinkerconnectedwithphenylalanine,akindofnew,safe,nontoxicadsorbentforendotoxiniscreated.Thismaterialhasagoodselectivityabilityandhigheradsorptionrate,whileneedslesstimetoreachequilibriumwiththeprospectsofclinicalapplication.Keywords:Endotoxin,Heparin,Phenylalanine,HemoperfusionMaterial目录中文摘要..........................................................................................................................................I英文摘要........................................................................................................................................II1引言.........................................................................................................................................11.1内毒素的性质.......................................................................................................................11.1.1内毒素的分子结构.......................................................................................................11.1.2内毒素的物理性质.......................................................................................................31.1.3内毒素的生物活性.......................................................................................................31.1.4内毒素的检测...............................................................................................................41.1.5内毒素的去除...............................................................................................................61.2内毒素血症...........................................................................................................................71.2.1内毒素血症的发病机理.......................................
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