肝素等硫酸多糖与粒细胞集落安慰因子等蛋白质在分子和细胞水平上的相互作用研究
Abs仃act
Abstract
Aiye
LiaIlg(AnalyticalChemist巧)
DirectedProfD Lin
and Du
by r.BingchengProf.1Y_uguang
Sulfhted acerltral
polysaccharidesplay r01e血manybiologicalprocesses
incl枷ng a11ddi腩rentiation
signaling,cellgroⅢh
ofmeintemctionsis in
InVestigation
proteins. importaIltuIlderstallding
biochemicala11d can me
alsoaccelerate
physi0109icalprocesses,a11d developmem
ofnew mesis theinteractions
carbohydrate出ased studied between
dmgs.This
sulfated and
hep撕n—like p01ysaccharidesproteinsincludinggranuloc)rte
factor
colony—stimulating by
(G—CSF)capiUaryelectrophoresis(CE),high
perfo衄anceliquidchromatogr印hy(HPLc),massflow
cytome乜_y(FC),etc.
Theinteractionsbetween a11ddi髓rent of were
h印arin typesprote血s
zonc wasfoulldthatCzEcould
bycapillary
investigated electrophoresis(CZE).It
be and
usedinbothslowf瓠ton—and—o行kinenc constaIltsof
systems.The
binding
were
granmocyte—macrophagccolony—stimulatingf砬tor(GM—csF)withh印arm
detemlinedforthefirst alsofollndmat
time.n GM-CSFcould
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