肝素等硫酸多糖与粒细胞集落安慰因子等蛋白质在分子和细胞水平上的相互作用研究.pdf

肝素等硫酸多糖与粒细胞集落安慰因子等蛋白质在分子和细胞水平上的相互作用研究.pdf

肝素等硫酸多糖与粒细胞集落安慰因子等蛋白质在分子和细胞水平上的相互作用研究

Abs仃act Abstract Aiye LiaIlg(AnalyticalChemist巧) DirectedProfD Lin and Du by r.BingchengProf.1Y_uguang Sulfhted acerltral polysaccharidesplay r01e血manybiologicalprocesses incl枷ng a11ddi腩rentiation signaling,cellgroⅢh ofmeintemctionsis in InVestigation proteins. importaIltuIlderstallding biochemicala11d can me alsoaccelerate physi0109icalprocesses,a11d developmem ofnew mesis theinteractions carbohydrate出ased studied between dmgs.This sulfated and hep撕n—like p01ysaccharidesproteinsincludinggranuloc)rte factor colony—stimulating by (G—CSF)capiUaryelectrophoresis(CE),high perfo衄anceliquidchromatogr印hy(HPLc),massflow cytome乜_y(FC),etc. Theinteractionsbetween a11ddi髓rent of were h印arin typesprote血s zonc wasfoulldthatCzEcould bycapillary investigated electrophoresis(CZE).It be and usedinbothslowf瓠ton—and—o行kinenc constaIltsof systems.The binding were granmocyte—macrophagccolony—stimulatingf砬tor(GM—csF)withh印arm detemlinedforthefirst alsofollndmat time.n GM-CSFcould

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