预注帕瑞昔布钠对经尿道前列腺电切术患者术后il-6、il-10、tnf-α的影响-effect of pre-injection of parecoxib sodium on il - 6, il - 10 and tnf - α after transurethral resection of prostate.docxVIP

目录中文摘要······························································································· （1） 英文摘要······························································································· （2） 论文题目······························································································· （4） 材料与方法···························································································· （5） 结果··································································································· （9） 讨论··································································································· （13） 结论··································································································· （15） 参考文献····························································································· （16） 文献综述····························································································· （19） 参考文献····························································································· （31） 缩略语表····························································································· （35） 攻读学位期间发表文章情况····································································· （36） 个人简历····························································································· （37） 致谢··································································································· （38）中 文 摘 要摘要 目的 观察经尿道前列腺电切术患者术前预注帕瑞昔布钠对术后各时段炎性因子 的影响,从而探讨经尿道前列腺电切术预注帕瑞昔布钠对炎症反应所起到的作用。 方法 选择择期行经尿道前列腺电切术患者 24 例，年龄在 50 岁到 65 岁之间，除前列腺增生 病变外，无其它基础性疾病，麻醉分级按美国 ASA 分级为 I-II 级，手术均选择腰硬联 合麻醉方式，麻醉平面均维持在 T10 以下，随机分组，分成帕瑞昔布钠组（A 组，n=12） 和对照组（B 组，n=12）。A 组于术前 30 分钟静脉注射由 5ml 0.9%氯化钠注射液溶解的 注射用帕瑞昔布钠 40mg，B 组注射 0.9%氯化钠注射液 5ml，分别于手术开始时（T1）， 手术完成时（T2），手术后 4 小时（T3），手术后 6 小时（T4）抽取静脉血液样本 5ml， 采用酶联免疫吸附法（enzyme linked immunosorbent assay，即 ELISA 法）测定血液 白介素-6（IL-6），白介素-10（IL-10），肿瘤坏死因子（TNF-α）的浓度水平。结果： A 组与 B 组在 T2 时刻，T3 时刻，T4 时刻血清中血液白介素-6（IL-6），白介素-10（IL-10）， 肿瘤坏死因子（TNF-α）的浓度水