原发性高血压患者血压变异性与肾功能损害相关性研究.docVIP

原发性高血压患者血压变异性与肾功能损害相关性研究 　　[摘要] 目的:观察原发性高血压患者血压变异性对肾功能损害的影响。方法:对86例轻中度原发性高血压患者按24 h收缩压血压变异性均值递增顺序分为EH1组(43例)和EH2组(43例)。进行24 h动态血压监测和24 h尿微量清蛋白及肾功能生化测定,观察并比较患者血压变异性对肾功能损伤的影响。结果:两组患者血压变异性有非常显著性差异(P0.05);24 h尿微量清蛋白有非常显著性差异(P0.05)。结论:原发性高血压患者血压变异性与高血压性肾脏损伤密切相关。 　　[关键词] 原发性高血压;血压变异性;肾脏损害;尿微量清蛋白 　　[中图分类号] R544.1[文献标识码]A [文章编号]1673-7210(2010)04(a)-058-03 　　 　　The relevant research between hypertension variability and renal dysfunction in primary high blood pressure patients 　　LIN Tao1, DING Yuanfang1, ZHANG Shulan2 　　(1.Department of Nephrology, Dalian Friendship Hospital, Dalian116001, China; 2.Department of Electrocardiogram, Central Hospital of Dalian City, Dalian 116033, China) 　　[Abstract] Objective: To evaluate the association between blood pressure variability and renal function injury in the patients with essential hypertension. Methods:86 cases of patients with mild to moderate essential hypertension were divided into EH1 group (43 cases) and EH2 group (43 cases) based on the mean variability of 24 h systolic blood pressure in ascending order. 24 h ambulatory blood pressure, quantitative of 24 h urine microalbumin and renal function determination were recorded. Results: The blood pressure variability of two groups has a significant difference (P0.05),the quantitative of 24 h urine microalbumin of two groups were significant difference (P0.05). Conclusion: Blood pressure variability is closely related with hypertensive renal injury in the patients with essential hypertension. 　　[Key words] Essential hypertension; Blood pressure variability; Renal injury; Urine microalbumin 　　 　　近年来随着动态血压监测在临床的广泛应用,人们对血压变异性的认识和研究不断深入。原发性高血压患者靶器官损害不仅与24 h平均动态血压有关,而且与24 h血压波动程度也密切相关。本研究探讨原发性高血压患者血压变异性(BPV)与肾功能损害的关系,进一步阐明BPV对肾功能的影响。 　　1 资料与方法 　　1.1 一般资料 　　选择大连市友谊医院内科2006年1月～2008年12月轻中度原发性高血压(EH)患者86例,其中,男47例,女39例;平均年龄(54.52±12.71)岁。原发性高血压的诊断符合1999年WHO/ISH高血压治疗指南的原发性高血压诊断标准。以上患者入院时未服用降压药或者已经停药2周以上,并经临床和实验室检查排除继发性高血压及有严重心脑血管病、糖尿病、严重肝肾病变者、不能从事日常活动者及从事夜班工作者。将86例原发性高血压患者按24 h