新生儿缺氧缺血性脑病血清IL-8水平与脑血流变化临床研究.docVIP

新生儿缺氧缺血性脑病血清IL-8水平与脑血流变化临床研究 　　【摘要】 目的 研究新生儿缺氧缺血性脑病（HIE）血清IL-8、脑血流变化水平与HIE脑损伤程度关系。方法 采用双抗体夹心ELSIA法检测41例不同程度HIE患儿、14例正常新生儿血清IL-8水平，同时采用经颅多谱勒超声（TCD）技术观察双侧大脑中动收缩峰流速(Vs)、舒张末期流速(Vd) 、脉动指数(RI)。结果 HIE患儿血清IL-8水平明显高于对照组 (P＜0．01),重度组增高尤其明显；中、重度组Vd、Vs低于对照组,RI指数重度组高于对照组(P＜0．05)。相关分析发现,急性期患儿血清IL-8水平与脑血流速度呈负相关,与脉动指数(RI)呈正相关。结论 检测血清IL-8和脑血流变化对判断HIE病情严重程度、指导治疗有一定临床意义。 　　【关键词】 新生儿;脑缺血;IL-8;脑血流 　　 　　Investigation of plasma interleukin-8 levels and hemodynamic changes in cerebral flow in neonatal hypoxic ischemic encephalopathyJIA Fei-fei，Xu De-en．Department of Gynaecology and Obstetrics，The First People Hospital of Panjin City，Liaoning 124010,China 　　【Abstract】 Objective To investigate the relationship of plasma interleukin-8 levels 、 hemodynamic changes in cerebral flow and brain damage in neonatal hypoxic ischemic encephalopathy（HIE）．Methods When the plasma interleukin-8 levels were detected using enzyme-linked immunoabsorbent assay(ELISA) in 41 neonatal hypoxic ischemic encephalopathy and 14 normal neonates，Systolic Velocity(Vs)，Diastolic Velocity(Vd) and aterial resistence index(RI) for middle cerebral artery(MCA) were detected by colour Doppler sonography．Results IL-8 level was much higher in HIE than in the control group，and IL-8 level was highest in three subgroup of HIE．Compared with those of the control groups，blood flow velocity in the moderate and severe groups decreased，while resistence index in severe group was higher than the control group．IL-8 level was significant negative correlation with blood flow velocity，but was significant positive correlation with resistence index．Conclusion The detection of serum IL-8 and blood flow velocity may be of value in the diagnosis of neonatal HIE and in the assessment of its severity． 　　【Key words】 Neonate；Cerebral ischemia；Interleukin-8；Blood flow velocity 　　 　　新生儿缺氧缺血性脑病(HIE)是新生儿期死亡和致残的重要疾病之一,早期???断及正确评估脑细胞损伤的严重程度有十分重要的意义。在新生儿缺氧缺血性脑病期,血清IL-8参与脑损伤的作用机制,但是关于HIE患儿血清中IL-8水平、脑血流动力学变化与脑缺氧损伤的程重相关性研究少有报道。本研究通过检测新生儿HIE血清IL-8水平以及脑血流