术前胆道引流对恶性阻塞性黄疸患者免疫炎症状况影响.docVIP

术前胆道引流对恶性阻塞性黄疸患者免疫炎症状况影响 　　[摘要] 目的：探讨术前胆道引流对恶性阻塞性黄疸患者免疫、炎症状况的影响。方法：选择于我院2008年6月～2010年3月就诊的43例恶性阻塞性黄疸患者作为研究对象，对患者进行术前胆道引流，以白细胞介素6（IL-6）、白细胞介素8（IL-8）、肿瘤坏死因子α（TNF-α）、CD4+、CD8+、C反应蛋白（CRP）为观察，指标比较引流前后患者的免疫、炎症状况。结果：引流后患者的IL-6、IL-8、、CD4+、CD8+、CRP分别为（40.8±7.0） ng/L、（1.37±0.26） μg/L、（34.7±3.0）、（28.±2.3）、（29.5±1.8）×103 mg/L，与引流前的（40.5±7.3） ng/L、（1.39±0.24） μg/L、（34.4±3.2）、（28.3±2.5）、（29.0±2.2）×103 mg/L比较，差异均无统计学意义（t=0.194 5、0.370 6、0.448 5、0.386 1、1.153 4，均P＞0.05）；引流后患者的TNF-α为（1.05±0.23） μg/L，与引流前的（1.42±0.25） μg/L比较，差异有统计学意义（t=7.1422，P＜0.05）。结论：术前胆道引流恶性阻塞性黄疸能够明显改善患者的TNF-α水平，TNF-α是恶性阻塞性黄疸患者免疫、炎症的敏感因子，值得临床关注。 　　[关键词] 恶性阻塞性黄疸；胆道引流；免疫；炎症 　　[中图分类号] R575[文献标识码]Ａ [文章编号]1673-7210（2011）03（b）-051-02 　　 　　Influence of preoperative biliary drainage in immune and inflammation of m alignant obstructive jaundice patients 　　ZOU Yuanhang1, MA Tao1, JIA Qianbin2 　　1.Department of Hepatobiliary Surgery, the First Affiliated Hospital of Shantou University Medical College, Shantou 515041, China; 2.Department of Biliary Surgery, the West China Hospital of Sichuan University, Chengdu 610041, China [Abstract] Objective: To explore the influence of preoperative biliary drainage in immune and inflammation of m alignant obstructive jaundice patients. Methods: From June 2008 to March 2010 in our hospital, 43 patients of m alignant obstructive jaundice were selected and as the research subjects, they were treated with preoperative biliary drainage, Interleukin 6 (IL-6), Interleukin 8 (IL-8), tumor necrosis factor α (TNF-α), CD4+, CD8+, C-reactive protein (CRP) were used as the indicator, the immune and inflammation conditions were observed before and after drainage. Results: After drainage, IL-6, IL-8, CD4+, CD8+, CRP of patients were (40.8±7.0) ng/L, (1.37±0.26) μg/L, (34.7±3.0), (28.5±2.3), (29.5±1.8)×103 mg/L, compared with (40.5±7.3) ng/L, (1.39±0.24) μg/L, (34.4±3.2), (28.3±2.5), (29.0±2.2)×103 mg/L before drainage, the differences were not statistically significant (t=0.1945, 0.3706, 0.4485