介孔涂层包覆镁合金材料的制备 降解和生物性能的分析-preparation, degradation and analysis of biological properties of magnesium alloy coated with mesoporous coating.docxVIP

ABSTRACTDuetothegoodmechanicalproperties,invitroandinvivobiocompatibility,anddegradability,magnesium(Mg)anditsalloyshavebeenregarded asthecandidatefortheapplicationasthebiodegradablebonerepairmaterialsrecently.However,theclinicuseofMgalloysismainlyrestrictedowingtothetoofastinitialcorrosionrateinbodyfluids.SurfacemodificationisanefficientwaytoprotectMgalloysandcontroltheircorrosionbehavior.Comparedwiththeconventionalcoatingsmaterials,mesoporousmaterialshave thenarrowdistributionof poresize,largespecificsurfaceareaandenhancedsurfacewettability,whichfavorforthepromotionofbiologicalpropertiesofthesubstrates.ItcouldbehypothesizedthatMgalloyscoatedwithmesoporouscoatingswouldexhibitsuitablepropertiesforbonerepair.Inthispaper,mesoporoushydroxyapatite(HA)andmesoporousHA/45S5glass-ceramic compositecoatings were respectivelypreparedontheglass orMgalloysubstatesusingasol-geldip-coatingmethod,andtheprocesswas optimizedtopreparetheuniformandcrack-freecoatings.MesoporousHAwithdifferentporestructurewaspreparedusingCTABorF127asthetemplatesbyvaringpHvalueandtemplateconcentration.Therein,themesoporousHApreparedusing0.192g/mLofF127templateachievedthemesoporessizedin3.17nm,anditsporevolumeandspecificsurfaceareawere0.38cc/gand211.7m2/g.Theuniformandcrack-freemesoporous coating with the thickness in ~1.0 μmwas prepared on Mg alloysubstrate.Usingsimulatedbodyfluids(SBF)asthecorrosionmedium,theinfluenceoftheporousstructureandcompositionofthecoatingsonthecorrosionbehaviorofMgalloywasstudied, andthemechanismofthemesoporouscoatingstopreventMgalloyfromrapidcorrosionwasexplored.Theimmersiontestsshowedthatthepresenceofmesoporousstructurewoulddeclinetheelasticmodulus of thecoatingandtheeffectofresidualstressonitsbreakdown,preventingtherapidcrackingandpeelingofHAcoatingintheinitialsoaking stageandpromotedtheprotectionofthemesoporousHAcoatingtothesubstrate.AftersoakinginSBFfor10days,thecorrosionrateofthemesoporousHAcoatedMgalloywas0.050mm/d,revealingthatthecoatedsamplehasgoodcorrosionresistance.Fur