运动应激对Th1和Th2偏移影响及其与Cor、BLA和BUN关系.docVIP

运动应激对Th1和Th2偏移影响及其与Cor、BLA和BUN关系 　　摘要：为了探索运动应激对Th1和Th2偏移的影响及其与皮质醇(Cor)、血乳酸(BLA)和血尿素氮(BUN)的关系。以非体育专业男大学生为研究对象，空腹，以200 W蹬车2 min，间歇5 min，重复运动至极度疲劳。检测运动前、运动后即刻和运动后3 h Th1型细胞因子干扰素-γ(IFN-γ)、Th2型细胞因子白细胞介素-4(IL-4)、T-淋巴细胞转换指数(T-LTI)、血清免疫球蛋白(IgG、IgA、IgM)以及血清皮质醇(Cor)、血乳酸(BLA)和尿素氮(BUN)浓度等。结果：IFN-γ、IFN-γ与IL-4比值和T-LTI在运动后即刻和运动后3 h分别下降了37%、30%、31%、31%、39%和28%(P＜0.001)；IL-4和血清IgG、IgA和IgM在运动前后无明显变化；血清Cor、BLA和BUN浓度在运动后即刻分别增加了的95%、314%、31%(P＜0.001)，休息3 h后仍无明显恢复。IFN-γ和IFN-γ与IL-4比值分别与T-LTI呈正相关(P＜0.05)。IFN-γ与IL-4比值分别与Cor、BUN、BLA以及IFN-γ分别与Cor、BUN之间均呈负相关(P＜0.05)；T-LTI分别与Cor、BLA、BUN呈负相关(P＜0.05)。IFN-γ与Ig以及IL-4与BLA、BUN无显著相关。结果说明运动应激时Th1和Th2向Th2方向偏移，细胞免疫功能下调。这些变化与血清Cor和BLA、BUN浓度增加有关。 　　关键词：运动应激；Th1型细胞因子干扰素-γ；Th2型细胞因子白细胞介素-4；皮质醇；血乳酸；尿素氮；T-淋巴细胞转换指数 　　中图分类号：G804.2文献标识码：A文章编号：1006-7116(2009)05-0095-05 　　 　　Effects of exercise stress on the deviation of Th1 and Th2 as well as 　　its relations with Cor, BLA and BUN 　　HE Wei 　　（School of Physical Education，Sichuan Normal University，Chengdu 610068，China） 　　 　　Abstract: In order to probe into the effects of exercise stress on the deviation of Th1 and Th2 as well as its relations with cortisol (Cor), blood lactic acid (BLA) and blood urea nitrogen (BUN), the author used male college students not majoring in physical education as the research subjects, who exercised to an extremely exhausted condition by repeatedly riding on a treadmill with 200 W of power for 2 min and then resting for 5 min in a stomach empty condition. The author tested the Th1 type cytokine, interferon-γ (IFN-γ), Th2 type cytokine, interleukin-4 (IL-4), T- lymphocyte transduction index (T-LTI), blood serum immunoglobulins (IgG, IgA and IgM), as well as the concentrations of blood serum Cor, BLA and BUN, before exercising, immediately after exercising and in 3 h after exercising, and revealed the following findings: IFN-γ, the radio of IFN-γ to IL-4 and T-LTI dropped respectively by 37%, 30%, 31%, 31%, 39% and 28% immediately after exercising and in 3 h after exercising (P＜0