陀螺旋转式钴60立体定向放射系统治疗食管癌疗效观察.docVIP

陀螺旋转式钴60立体定向放射系统治疗食管癌疗效观察 　　[摘要] 目的 观察陀螺旋转式钴60立体定向放射系统（陀螺刀）治疗食管癌的近期疗效和急慢性毒副反应。 方法 采用国产陀螺旋转式钴60立体定向放射系统治疗食管癌120例，全组处方剂量4 200～4 800 cGy，中位处方剂量4 500 cGy，350 cGy/次，5次/周，对其近期疗效及急慢性毒副反应进行评价。 结果 ①1年局部控制率为72.50%，1年总生存率为79.25%，1年无瘤生存率为71.18%。②全组患者完全缓解81例（67.50%），部分缓解38例（31.67%），无缓解1例（0.83%），肿瘤总有效率为99.17%。③急性放射性肺损伤0级101例（84.16%），1级19例（15.83%），无2、3、4级发生；晚期放射性肺损伤0级112例（93.33%），1级8例（6.67%），无2、3、4级发生；急性放射性食管损伤0级20例（16.67%），1级98例（81. 67%），2级2例（1.7%），无3、4级发生。晚期放射性食管损伤0级101例（84.17%），1级17例（14.17%），2级2例（1.67%），无3、4级发生。 结论 陀螺刀治疗食管癌初期疗效较好，急慢性放射性食管和肺损伤发生率较低，是一种有效的局部治疗方法，其远期疗效有待进一步观察。 　　[关键词] 食管癌；陀螺刀；疗效；预后 　　[中图分类号] R735.1[文献标识码] A[文章编号] 1673-7210（2012）03（c）-0054-03 　　Observation of therapeutic efficacy of cobalt-60 gyro rotating stereotactic radiotherapy in the treatment of esophageal cancer 　　HAN Wenfeng1ZHENG Yazhen2CHEN Yanrui3LI Xianliang4ZHANG Hongtao2AN Shuzhang5 　　1.Department of Oncology, the 7th Peoples Hospital, Hebei Province, Dingzhou 073000, China; 2.The Second Department of Surgical, the 7th Peoples Hospital, Hebei Province, Dingzhou 073000, China; 3.Department of Nursing, the 7th Peoples Hospital, Hebei Province, Dingzhou 073000, China; 4.Department of Functional, the 7th Peoples Hospital, Hebei Province, Dingzhou 073000, China; 5. Hebei Provincial Childrens Hospital, Hebei Province, Shijiazhuang 050020, China 　　[Abstract] Objective To observe the therapeutic efficacy acute and chronic toxicity of cobalt-60 gyro rotating stereotactic radiotherapy system (gyro knife) in the treatment of esophageal cancer. Methods 120 esophageal cancer patients were treated with gyro knife. The prescription doses of the group were 4 200 to 4 800 cGy and the median prescribed dose was 4 500 cGy. The dose was delivered at 350 cGy each time for 5 times a week. The efficacy and acute and chronic toxicity side effects were evaluated. Results ①1-year local control rate was 72.50%. 1-year overall survival rate was 79.25%. And 1-year survival rate was 71.18%. ② The treatment achieved complet