药对黄连吴茱萸对高血压大鼠血压和血浆ETCGRP影响.docVIP

药对黄连吴茱萸对高血压大鼠血压和血浆ETCGRP影响 　　 摘要:目的 观察药对黄连、吴茱萸对自发性高血压大鼠（SHR）血压和血管活性物质内皮素（ET）、降钙素基因相关肽（CGRP）含量的影响。方法 将24只SHR随机分为模型组（Model组）、硝苯地平组（Nif组）、连萸药对组（LY组），每组8只，以正常WKY大鼠为对照组(WKY组），8只，共4组。 WKY组和Model组予以生理盐水，Nif组予以硝苯地平溶液，中药组予以相应配伍剂量的浓煎剂，连续灌胃4周，测量大鼠灌胃前和灌胃4周末大鼠尾动脉的收缩压。第4周末同时测定大鼠血浆中ET、CGRP的含量。结果 与Model组比较，中药组大鼠4周后血压水平明显降低（P 　　 关键词：黄连；吴茱萸；高血压；内皮素；降钙素基因相关肽；高血压病；大鼠 　　 中图分类号：R544.1 R285.5 文献标识码：A 文章编号：1672 　　________________________________________ 　　1349（2011）09 　　________________________________________ 　　1079 　　________________________________________ 　　02 　　Effect of Drug Pair of Coptis Chinensis and Evodia Rutatecarpa on Blood Pressure， 　　Plasma Endothelin and Calcitonin Gene 　　________________________________________ 　　related Peptide in Spontaneous Hypertension Rats 　　Bu Xianzheng，Wu Huaqin，Hu Yuanhui，et al // China National Software and Service Co.Ltd (Beijing 102200) 　　 　　Abstract:Objective To investigate the effects of drug pair of coptis chinensis and evodia rutatecarpa on blood pressure，the content of plasma endothelin(ET)，and calcitonin gene 　　________________________________________ 　　related peptide (CGRP) in spontaneous hypertension rats（SHR）.Methods Twenty 　　________________________________________ 　　four SHR were randomly divided into model group(n=8)，nifedipine group(n=8) given nifedipine，and Lianyu decoction group(n=8) given Lianyu oral liquid by continuously gavages.Eight normal Wistar 　　________________________________________ 　　Kyoto rats(WKY) were as control (WKY group).WKY group and Model group were given normal saline.After treatment for 4 weeks，blood pressure，the content of plasma ET and CGRP were measured.Results Compared with model group，the blood pressure in Lian 　　________________________________________ 　　Yu decoction group was significantly lower (P＜0.01).The content of ET was decreased (P＜0.05)，while the content of plasma CGRP was greatly increased (P＜0.01) in Lianyu decoction group.Conclusion Drug pair of coptis chinensis and