肌营养不良实验鼠精品课件.ppt

The treatment of muscular dystrophy;The mdx mouse——肌营养不良实验鼠 ;;The treatment of pharmaceuticals;Gentamicin cure in mdx mice;Gentamicin cure in humen;Other discovery about this drug;The disadvantages of this drug;New chemical compound that is better than gentamicin ;Methods of Gene therapy;腺病毒作为载体;Using virus as the vector;Using virus as the vector;Using virus as the vector;Using virus as the vector;The comparison between Becker and Duchenne;The experimental evidence about this method;The experimental evidence about this method;The experimental evidence about this method;Plasmid-mediated gene therapy;Plasmid-mediated gene therapy;Plasmid-mediated gene therapy;Plasmid-mediated gene therapy;关于免疫应答问题;Summary ;Gene replacement therapy;Gene therapy;Exon skipping can change a DMD into a BMD;Splice sites are specific sequences at the borders of exons and introns which are essential for the correct removal of the non-coding intron sequences from the pre-mRNA. The splicing itself is accomplished by spliceosomes, a complex of many small RNAs and proteins whose details and interplay are still not completely understood. ;intron;For example ;Experiment;Experiment ;Gene therapy;The micro-Utrophin ;;利用utrophin进行的实验;The anther therapy;如何预防肌营养不良症; Thank you!;LcOfRiUlXo#s%v(y+B2E5H9KcNfQiTlWo#r%u(x+A2D5H8KbNeQhTkWoZr$u*x-A1D5G8JbMePhSkWnZq$t*w-z1D4G7JaMdPgSkVnYq!tw)z1C4F7IaLdOgSjVmYp!sv)z0C3F6I9LcOgRjUmXp#s%v)y0B3E6H9KcOfRiUlXo#r%v(y+B2E5H8KbNfQiTlWoZr$u(x+A2D5G8JbNeQhTkWnZq$u*x-A1D4G7JbMeSkWnZq$t*w-z1D4G7JaMdPgSkVnYq!tw)z1C4F7IaLdOgSjVmYp!sv)z0C3F6I9LcOgRjUmXp#s%v)y0B3E6H9KcOfRiUlXo#r%v(y+B2E5H8KcNfQiTlWoZr%u(x+A2D5G8KbNeQhTkWnZr$u*x-A1D4G8JbMePhSkVnZq$t*w-z1C4G7JaMdPgSjVnYq!tw)z0C3F7IaLdOgRjUmYp!sv)y0B3F6I9LcOfRiUmXp#s%v(y+B3E6H9KcNfQiUlXo#r%u(x+B2E5H8KbNeQiTlWoZr$u*x+A2D5G8JbMeQhTkWnZq$t*x-A1D4G7JaMePhSkVnYq!t*w-z1C4F7IaMdPgSjVmYp!tw)z0C3F6IaLdOgRjUmXp!sv)y0B3E6I9LcOfRiUlXp#s%v(y+B2E6H9KcNfQiTlXo#r%u(x+A2E5H8KbNeQhTlWoZr$u*x-A2D5G8JbMePhTkWnZq$t*w-A1D4G7JaMdPhSkVnYq!tw-z1C4F7IaLdP