437例冷冻胚胎移植结果相关影响因素分析.docVIP

437例冷冻胚胎移植结果相关影响因素分析 　　[摘要] 目的 探讨冷冻胚胎移植（FET）结果的相关影响因素。 方法 回顾性分析2008年1月～2012年6月在广东省妇幼保健院生殖中心进行FET周期中437例患者的临床资料，探讨年龄、子宫内膜准备方案、子宫内膜厚度、胚胎类型及移植时间对FET结果的影响。 结果 获得临床妊娠171例（39.14%），子宫内膜厚度 0.05）；年龄、与移植细胞胚胎类型及移植时间选择排卵后第3天或第4天这两组间的临床妊娠率差异有统计学意义 （P 10个细胞期单胚胎/M期胚胎及2或3个M期胚胎均可增加妊娠率，而后者妊娠成功的可能性更大（OR = 3.225、4.671）。移植时间选择排卵后4 d（自然周期）或者黄体酮（40 mg/d）转化4 d相对于3 d者其妊娠可能更大（OR = 1.986）。 结论 患者年龄、子宫内膜的准备、胚胎类型和数目、移植时间选择均可对FET的结果造成影响。 　　[关键词] 冷冻胚胎移植；妊娠率；影响因素 　　[中图分类号] R711.6 [文献标识码] A [文章编号] 1673-7210（2013）11（c）-0048-04 　　Analysis of influencing factors on 437 cases frozen-thawed embryo transfer 　　DONG Mei YI Yanhong CHEN Chuangqi LIU Fenghua HUANG Cuiyu ZHANG Xiqian 　　Department of Reproductive Health and Infertility， Guangdong Women and Children Hospital， Guangdong Province， Guangzhou 510403， China 　　[Abstract] Objective To explore the influencing factors on frozen-thawed embryo transfer（FET）. Methods Clinical datas of 437 patients in FET cycles from January 2008 to June 2012 in the Reproductive Center of Guangdong Women and Children Hospital were retrospective analyzed. The age， preparation programs of endometrium for transfer， endometrium thickness， embryo types， and the implantation time of cryopreserved human embryo were discussed. Results 171（39.14%） patients acquired clinical pregnancy， there was no significant difference between the patients whose endometrium thickness 0.05）， the clinical pregnancy rate in different age and embryo types， and clinical pregnancy rate in difference implantation time of 3 and 4 days after ovulation had significant difference （P 10 or M period embryos， and 2 or 3 M period embryos were increased， and the later one had a higher odds （OR = 3.225， 4.671）. The pregnancy rate after FET was increased in the 4 days after ovulation （natural period） or the Progesterone （40 mg/d） conversion 4 days had a higher pregnancy rate than the 3 days （OR = 1.986）. Conclusion The age of Patients， preparation of endometrial， types and number of implantation embryo， an