在晚起鼻咽癌中表达与不良预后课件.pptVIP

Expression of syndecan-1 (CD138) in nasopharyngealcarcinoma is correlated with advanced stage andpoor prognosis 1. Introduction Nasopharyngeal carcinoma (NPC) is one of the most common cancers in Taiwan . Most patients have stage III or more advanced disease at the time of diagnosis . Nasopharyngeal carcinoma can be cured by radiotherapy alone or combined chemoradiotherapy, but recurrent or distant metastasis is common and the outcome of patients with recurrent or metastatic NPC remains poor. Still, with primary tumors, the initial 5-year survival rate is approximately 60% to 70% . Nasopharyngeal carcinoma is an Epstein-Barr virus (EBV)–associated malignancy that expresses a limited number of latent EBV genes, including Epstein-Barr nuclear antigen-1, latent membrane protein-1 (LMP-1), latent membrane protein-2A (LMP-2A). Latent membrane protein-1 can induce the expression of epithelial growth factor receptor in epithelial cells . LMP-1 has been shown to possess potent tumorigenic effect and promote tumor cell metastasis Epithelial malignancy metastasis and tumor invasion are a multistep process involving several crucial events: the loosening of intercellular junctions, attachment of tumor cells to the extracellular matrix (ECM), degradation of the ECM, migration of tumor cells through the ECM, angiogenesis, detachment of tumor cells, vascular permeation, the homing of tumor cells and trafficking of cancer cells through blood vessels, extravasations, organ-specific homing, and growth . Numerous molecules are involved in tumor invasion and metastasis, particularly heparin sulfate proteoglycans , which can interact with various effector molecules, such as ECM molecules and growth factors ,and are modulators of cell growth and differentiation. Syndecans belong to a family of cell surface prote