白藜芦醇抗抑郁作用及机制分析-antidepressant effect of resveratrol and its mechanism analysis.docxVIP

ContentsAbstract．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．4Abbreviations．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．71．Introduction．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．92．Classificationofdepression．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．1()3．RationaleforusingtheCMSanimalmodelofdepression．154．Pathophysiologyofdepression．．175．Treatmentofdepression．236．Prevalenceofdepression257．Prognosisofdepression．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．：168．Aimsofthisthesis．．279．RelationshipbetweenResveratr01．PGC—laandSLRTl2710．Materialsandmethods2910．1．Subjects．2910．2．Drugs．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．：2：910．3．Chronicmildstress2910．4．Experimentaldesign．3010．4．1．Schematicofbehaviouraltestbattery．．3010．4．2．Sucrosepreferencetest．3010．4．3．Openfieldtest3l10．4．4．Elevatedplus-maze．3110．4．5．Socialinteractiontest．3210．4．6．Forcedswimtest3210．4．7．Tailsuspensiontest3310．5．Immunofluorescentstaining．3310．6．Westernblotting334万方数据10．7．Statisticalanalysis．3411．Itesults．3411TheeffectsofResveratrolonboayweightinmice．34i13TheeffectsofResveratrolondurationintheopenfieldtest36l2TheeffectsofRSVonsucrosepreferenceinmice．_351l4TheeffectsofResveratrolonfrequencyanddurationintheelevatedplus—maze．．37l15TheeffectsofResveratrolonfrequencyanddurationinthesocialinteractiontest．．3716TheeffectsofResveratrolonimmobilitytimeintheforcedswimtest一39l■ll7TheeffectsofResveratrolonimmobilityinthetailsuspensiontest．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．：；9l18TheimmunofluorescencestainingofSIRTIandPGC—lainthehippocampus．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．40l19ThewesternblottingresultsofSIRT1andPGC-lainthehippocampus4l12．Discussion．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．．4313．Conclusion．．．．．．．．．．．．．．