臂丛神经根撕脱导致运动神经元死亡的过氧化机制及egb761的保护作用-peroxidation mechanism of motor neuron death caused by brachial plexus root avulsion and protective effect of egb 761.docxVIP
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臂丛神经根撕脱导致运动神经元死亡的过氧化机制及egb761的保护作用-peroxidation mechanism of motor neuron death caused by brachial plexus root avulsion and protective effect of egb 761
臂丛神经根撕脱导致运动神经元死亡的过氧化机制及EGb761的保护作用软件进行方差分析,ANOVA观察组内和组间差异,校正后组间比较采用t检验。结果:血清NO含量(utool/L),撕脱组:5d为59.86+2.79,2w为87.88±0.98,4w为78.09±1.90,6w为73.34+1.83;EGb76150mg/kg.d组:5d为58.83±4.1l,2w为83.42±2.45,4w为76.OO±2.67,6w为70.50±2.00:EGb761lOOmg/kg.d组:5d为57.76+4.27,2w为80.47+2.55,4w为72.95±1.06,6w为68.65±3.09。5d时间点三组间差异无显著意义,F=O.561,P=0.58:2w时间点三组间差异有非常显著意义,F=15.48,P0.001,其中撕脱组高于EGb76150mgg.d组,t=3.773,P=0.012、也高于EGb761100mg/kg,d组,t一6.066,P=O.002、两个EGb761组之间的差异无显著意义,t=1.865,P=0.099;4w时间点三组间差异有非常显著的意义,F=13.493,P0.001,其中撕脱组高于EGb761100mg/kg.d组,t=6.664,P0.001、EGb76150m/kg.dg组也高于EGb761100mg/kg.d组t=3.001,P=0.015、撕脱组与EGb76150mg/kg.d组之间的差异无显著意义,t=1.803,P=O.095;6w时间点三组间的差异有显著意义,F=7.649,P;0.004,其中撕脱组高于EGb76150mgg.d组,t=2.876,P=0.014、也高于EGb761100mg/kg.d组,t=3.517,P=0.006、两个EGb761组之间的差异无显著意义,t=1.329,P=0.213。‘损伤脊髓组织NO含量(umoI/L),撕脱组:5d为0.089±0.01l,2w为0.379±0.027,4w为0.303±O.026,6w为O.225±0.026;EGb76150mgg.d组:5d为0.088±O.010,2w为0.305±O.020,4w为O.254±0.044,6w为0.192±0.027;EGb761100mgg.d组:5d为0.0879±0.021,2w为0.268±0.012,4w为0.223±O.018,6w为0.174±0.027。5d时间点三组间差异无显著意义,F=0.009,P=0.991;2w时间点三组间差异有非常显著意义,F一38.751,P0.001,其中撕脱组高于EGb76150mgg.d组,t=5.968,P0.001、也高于EGb761100mg/kg.d组,t=4.998,P=0.001、EGb76150mgg.d组高于EGb761100mg/kg.d组,t=3.522,P=0.01l;4w时间点三组间差异有非常显著的意义,F=13.256,P0.001,其中撕脱组高于EGb76150mgg.d组,户2.724,P=0.019、也高于EGb761100mgmg.d组,t=7.16,P0.001、两个EGb761组之间的差异无显著意义,t=1.814,P=0.103;6w时间点三组间的差异有显著意义,F=6.249,P=O.008,II臂丛神经根撕脱导致运动神疑元死亡的过氧化机制及EGb76I的保护作用其中撅脱组高子EGb76150mg/kg.d缀,t=2.650,P=O.019、也高于EGb761lOOmgg.d组,t=3.235,P=O.006、两个EGb761组之间的藏羿无显著意义,t=0.86.P=0.40。损伤蠢髓组织cNOS含量(U/m1),撅脱组:键强O.0451±O.0034,2w势O.2033±0.0073,4w为0.1417±0.0224,6w为0.0884士0,0204;EGb76150mgg.d组:5d为O.0448±O.0056,2w为0.1638±0.0128,4w为0.0979±0+0246,6w为O.0725±O,0092;EGb761100mgg+d维:5d为O。0434士0。0062,2w海O。t276+0。0143,4w灸0.0717±0.0135,6w为O.0656_+0.0177。5d对橱点三缝褥差异无显著爨义,F=0.222,P=0.803;2w时间点三组间差异有非常驻著意义,Fm51.409,P0.001,其中撅脱缀衰予EGb76150mgg.d组,t一5.968,P0.001、墩离于EGb761100mg/kg.d缀,t=10.657,P0.001、EGb76150mg/kg.d组高于EGb761100mg/kg.d组,t。4,238,P;O.03;4w时间点三组间差异有jE常显
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