慢性粒细胞白血病双语.pptVIP

healthy physical examination and found the white blood cells increased. 患者，马**，男，54岁，主因“体检发现白细胞增高，脾脏肿大1周”入院。 查体：皮肤、巩膜无黄染，浅表淋巴结无肿大，胸骨压痛+，脾大平脐，质中等 * * Is a kind of malignant myeloproliferative disease happened in the early pluripotent hematopoietic stem cells phase is mainly concerned with myeloid development, develops relatively slow. * It occurs at all ages (incidence of 1 cases/million population, median age 50-60 years, male/female ratio equal) The important landmarks in the study of CML were the discovery of the Philadelphia (Ph) chromosome and the characterization of the BCR–ABL fusion gene.任何年龄均可发病，发病率约1/10万， 占白血病的第3位；中位年龄以50-60岁为高峰；男：女 1:1。 CML的标志性染色体是Ph1染色体(chromosome )和BCR/ABL融合基因(fusion gene)。 * * * This figure shows all the 23 pair chromosome. human DNA is packaged in 23 pairs of chromosomes) The chromosome 22 pointed by red arrow show the main portion of the long arm is deleted. Fever but no reason, anemia, aggravated bleeding or pain; Progressive enlargement of the spleen; 20% basophil in peripheral blood; thrombocytopenia or reduced but no reason; Drug resistance; The emergence of new chromosome abnormalities:+8, double Ph1 chromosome, i17q * The end of the stage, performance similar to acute leukemia; The prognosis is very poor, and the overall survival is only a few months; * At the end of this lecture ,I will show you all a picture , * 慢性粒细胞白血病Chronic Myeloid Leukemia The 2nd Hospital of Shanxi Medical University Hematology Department Is leukemia far from our life? Is leukemia really terrible? Can leukemia be cured? Do they need to accept the bone marrow transplantation? Is it useful to diagnose it earlier? 生词本 * A typical case report Patient, Ma * *, male, 54 years old, main complain “physical examination found leucocytosis, splenomegaly for 1 week”. Physical examination: no jaundice, no enlarged lymph nodes, no bleeding, sternal palpation +, medium splenomegaly. * A typical case report 血常规 白细胞 350×109/L， 血