中医疏肝益肾健脾凉血化瘀毒法治疗乙型肝炎肝纤维化肝硬化疗效分析.docVIP

中医疏肝益肾健脾凉血化瘀解毒法治疗乙型肝炎肝纤维化肝硬化疗效分析 　　[摘要] 目的 ?^察自拟疏肝益肾健脾凉血化瘀解毒中药复方治疗乙型肝炎肝纤维化肝硬化的临床疗效。方法 随机选取2015年11月―2017年5月在该院门诊及住院的乙肝肝硬化患者80例，分层后随机分为两组，两组基线均衡具可比性。入组患者都是口服恩替卡韦分散片（润众）满两年疗程中的患者，治疗组入组后联合口服自拟的具有疏肝益肾健脾凉血化瘀解毒作用的中药复方，1付/d，水煎服，早晚饭后30 min各150 mL，对照组是自愿单独口服润众抗病毒治疗的患者，疗程3个月。治疗前和治疗3个月后对其症状、体征、肝功能、肾功能、HBVDNA、血清肝纤维化指标、肝脏B超和肝脏瞬时弹性测定（Fibroscan）结果进行记录和分析。 结果 肝功能、HBVDNA：治疗组：治疗后与治疗前比较：白蛋白上升、γ-球蛋白下降皆差异有统计学意义（P0.05）。HBVDNA：两组治疗前后皆低于检测值。血清肝纤维化指标：治疗组：治疗后与治疗前对比及治疗后与对照组比较皆有明显改善，差异有统计学意义（P0.05）。B超及肝脏瞬时弹性扫描（Fibroscan）：治疗组：治疗后与治疗前对比且与对照组治疗后比较，肝脏门静脉宽度、脾脏厚度、Fibroscan值明显下降差异有统计学意义（P0.05）。 结论 依中医疏肝益肾健脾凉血化瘀解毒法组复方治疗乙肝肝硬化，有肯定的疗效，有进一步研究和临床推广价值。 中国论文网 /6/viewhtm　　[关键词] 中医；疏肝益肾健脾凉血化瘀解毒法；治疗；乙型肝炎肝硬化 　　[中图分类号] R725 [文献标识码] A [文章编号] 1674-0742（2017）09（c）-0001-03 　　Analysis of Curative Effect of Shugan Yishen Jianpi Liangxue Huayu Jiedu Method in Treatment of Fibrosis with Hepatitis B 　　LI Wei， WU Wei， SUN Shu-lun， WANG Ming-min 　　Department of Integrated Traditional and Western Medicine， Sixth Peoples Hospital of Qingdao， Qingdao， Shandong Province， 266000 China 　　[Abstract] Objective To observe the clinical curative effect of Chinese herbal compound of shugan yishen jianpi liangxue huayu jiedu method in treatment of fibrosis with hepatitis B. Methods 80 cases of outpatients and inpatients with hepatitis B cirrhosis from November 2015 to May 2017 were randomly selected and randomly divided into two groups with 40 cases in each， all patients took entecavir dispersible tablets （runzhong） orally for two years， the treatment group took the self-made Chinese herbal compound of shugan yishen jianpi liangxue huayu jiedu once a day， decocted in water， 150 mL in half an hour after breakfast and dinner， the control group were the patients taking the runzhong anti-virus treatment voluntarily and the treatment course was 3 months， and the symptoms， vital signs， liver function， renal function， HBVDNA， serum hepatic fibrosis index， liver B ultrasound and Fibro scan were recorded and analyzed. Results The album